超声引导下微波消融联合TACE治疗复发性肝癌的近期疗效及对患者肝功能、免疫功能的影响OA
The Short-Term Efficacy of Ultrasound-Guided Microwave Ablation Combined with TACE for Recurrent Hepatocellular Carcinoma and Its Influence on Liver and Immune Function
目的 探讨超声引导下微波消融联合经动脉化疗栓塞术(TACE)治疗复发性肝癌的近期疗效及对患者肝功能、免疫功能的影响.方法 回顾性选取2023年1月至2025年1月沧州市中心医院收治的120例复发性肝癌患者.根据治疗方案将患者分为联合组(62例)与对照组(58例).联合组接受超声引导下微波消融联合TACE治疗,对照组仅接受TACE治疗.比较两组患者治疗后3个月的近期疗效;记录两组治疗前后肝功能指标(天冬氨酸氨基转移酶、丙氨酸氨基转移酶、总胆红素)、免疫功能指标(CD3+、CD4+T淋巴细胞百分比、自然杀伤细胞活性)变化及不良反应发生情况.结果 联合组治疗总有效率为72.58%,高于对照组的44.83%(P<0.05).治疗后,两组患者血清天冬氨酸氨基转移酶、丙氨酸氨基转移酶及总胆红素均降低,且联合组低于对照组(均P<0.05).治疗后,两组患者CD3+、CD4+、自然杀伤细胞水平均显著升高,且联合组显著高于对照组(均P<0.05).对照组与联合组不良反应发生率比较,差异无统计学意义(P>0.05).结论 超声引导下微波消融联合TACE治疗复发性肝癌近期疗效确切,有助于改善肝功能并增强免疫功能,且近期安全性良好.
Objective To explore the short-term efficacy of ultrasound-guided microwave ablation combined with transcatheter arterial chemoembolization(TACE)for recurrent hepatocellular carcinoma and its impact on liver function and immune function in patients.Methods A total of 120 patients with recurrent hepatocellular carcinoma admitted to Cangzhou Central Hospital from January 2023 to January 2025 were retrospectively enrolled.According to the treatment regimen,patients were divided into the combined group(n=62)and the control group(n=58).The combined group received ultrasound-guided microwave ablation combined with TACE,while the control group received TACE alone.The short-term efficacy was compared between the two groups at 3 months after treatment;changes in liver function indicators(aspartate aminotransferase,alanine aminotransferase,total bilirubin)and immune function indicators(CD3+,CD4+T lymphocyte percentage,natural killer cell activity)before and after treatment,as well as the occurrence of adverse events,were recorded.Results The total effective rate in the combined group was 72.58%,which was higher than that in the control group(44.83%)(P<0.05).After treatment,serum levels of aspartate aminotransferase,alanine aminotransferase,and total bilirubin in both groups decreased,and those in the combined group were lower than those in the control group(all P<0.05).After treatment,the levels of CD3+,CD4+T lymphocytes,and natural killer cell activity in both groups increased significantly,and those in the combined group were significantly higher than those in the control group(all P<0.05).There was no statistically significant difference in the incidence of adverse events between the control group and the combined group(P>0.05).Conclusion Ultrasound-guided microwave ablation combined with TACE shows definite short-term efficacy in the treatment of recurrent hepatocellular carcinoma,helps improve liver function and enhance immune function,and demonstrates good short-term safety.
付晓丹;顾丽婕;白文仓;伏晨卉;徐娟;崔永慧;于楠
沧州市中心医院超声医学中心,河北 沧州 061000沧州市中心医院超声医学中心,河北 沧州 061000沧州市中心医院超声医学中心,河北 沧州 061000沧州市中心医院超声医学中心,河北 沧州 061000沧州市中心医院超声医学中心,河北 沧州 061000沧州市中心医院超声医学中心,河北 沧州 061000沧州市中心医院超声医学中心,河北 沧州 061000
复发性肝癌微波消融经动脉化疗栓塞肝功能免疫功能疗效
recurrent hepatocellular carcinomamicrowave ablationtranscatheter arterial chemoembolizationliver functionimmune functionefficacy
《转化医学杂志》 2026 (6)
923-927,5
河北省卫生健康委员会2022年度医学科学研究课题计划项目(20220376)
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