淋巴瘤患者化疗期间焦虑抑郁变化轨迹及影响因素研究OA
A Study on the Trajectory of Anxiety and Depression and Influencing Factors in Patients with Lymphoma During Chemotherapy
目的 探讨淋巴瘤患者化疗期间焦虑、抑郁的变化轨迹及影响因素.方法 选取2023年3月至2024年2月空军军医大学唐都医院接受化疗的淋巴瘤患者为研究对象.于开始化疗前(T0)使用一般资料调查问卷收集其人口学及临床资料,于T0时、第1次化疗结束时(T1)、第2次化疗结束时(T2)、第3次化疗结束时(T3)、第4次化疗结束时(T4)、第5次化疗结束时(T5)采用医院焦虑抑郁量表(HADS)评估其焦虑、抑郁水平;采用广义估计方程模型分析淋巴瘤患者化疗期间焦虑、抑郁的影响因素.结果 T0、T1、T2、T3、T4、T5时58例淋巴瘤患者焦虑检出率分别为70.69%、94.83%、96.55%、79.31%、44.83%、15.52%,抑郁检出率分别为65.52%、89.66%、94.83%、75.86%、39.66%、12.07%.T0、T1、T2、T3、T4、T5时HADS-焦虑亚量表评分分别为(9.22±1.51)分、(12.07±2.58)分、(14.83±2.23)分、(10.40±1.72)分、(6.76±1.37)分、(2.67±0.80)分,HADS-抑郁亚量表评分分别为(8.93±1.66)分、(11.40±1.72)分、(14.14±2.67)分、(9.69±1.70)分、(6.47±1.84)分、(2.59±0.79)分.广义估计方程模型分析显示,文化程度(OR=0.460,95%CI:0.295～0.625)、家庭人均月收入(OR=0.489,95%CI:0.352～0.679)、手术史(OR=2.408,95%CI:1.647～3.523)、疾病分期(OR=2.547,95%CI:1.711～3.792)是淋巴瘤患者化疗期间焦虑的影响因素(P<0.05);性别(OR=1.914,95%CI:1.401～2.613)、文化程度(OR=0.469,95%CI:0.330～0.666)、婚姻状况(OR=2.298,95%CI:1.580～3.341)、家庭人均月收入(OR=0.389,95%CI:0.260～0.582)是淋巴瘤患者化疗期间抑郁的影响因素(P<0.05).结论 淋巴瘤患者化疗期间普遍存在焦虑、抑郁症状,焦虑、抑郁评分呈先升后降的轨迹,于化疗中期达到峰值,且与文化程度、家庭人均月收入、手术史、疾病分期等因素相关.
Objective To analyze the trajectory and influencing factors of anxiety and depression in patients with lymphoma during chemotherapy.Methods A total of 58 patients with lymphoma(n=58)who received chemotherapy at Tangdu Hospital of Air Force Medical University from March 2023 to February 2024 were selected as study subjects.A general information questionnaire was used to collect demographic and clinical data before chemotherapy initiation(T0).The Hospital Anxiety and Depression Scale(HADS)was used to assess anxiety and depression levels at T0,at the end of the first chemotherapy(T1),at the end of the second chemotherapy(T2),at the end of the third chemotherapy(T3),at the end of the fourth chemotherapy(T4),and at the end of the fifth chemotherapy(T5).Generalized estimating equation models were applied to analyze the influencing factors of anxiety and depression in patients with lymphoma during chemotherapy.Results The detection rates of anxiety at T0 to T5 were 70.69%,94.83%,96.55%,79.31%,44.83%,and 15.52%,respectively,and the detection rates of depression were 65.52%,89.66%,94.83%,75.86%,39.66%,and 12.07%,respectively.The scores of HADS-Anxiety subscale(HADS-A)at T0 to T5 were 9.22±1.51,12.07±2.58,14.83±2.23,10.40±1.72,6.76±1.37,and 2.67±0.80,respectively,and the scores of HADS-Depression subscale(HADS-D)were 8.93±1.66,11.40±1.72,14.14±2.67,9.69±1.70,6.47±1.84,and 2.59±0.79,respectively.Generalized estimating equation model analysis showed that educational level(OR=0.460,95%CI:0.295-0.625),family per capita monthly income(OR=0.489,95%CI:0.352-0.679),surgical history(OR=2.408,95%CI:1.647-3.523),and disease stage(OR=2.547,95%CI:1.711-3.792)were influencing factors for anxiety in patients with lymphoma during chemotherapy(P<0.05);gender(OR=1.914,95%CI:1.401-2.613),educational level(OR=0.469,95%CI:0.330-0.666),marital status(OR=2.298,95%CI:1.580-3.341),and family per capita monthly income(OR=0.389,95%CI:0.260-0.582)were influencing factors for depression in patients with lymphoma during chemotherapy(P<0.05).Conclusion Anxiety and depression symptoms are common in patients with lymphoma during chemotherapy.The scores of anxiety and depression show a trajectory of increasing first and then decreasing,peaking in the middle of chemotherapy,and are associated with educational level,family per capita monthly income,surgical history,disease stage and other factors.
张倩;秦炜炜;王黎红;高晓彤;周倩;张晓;户小红;赵利
空军军医大学唐都医院血液内科,西安 710038空军军医大学唐都医院血液内科,西安 710038空军军医大学唐都医院血液内科,西安 710038空军军医大学唐都医院血液内科,西安 710038空军军医大学唐都医院血液内科,西安 710038空军军医大学唐都医院血液内科,西安 710038空军军医大学唐都医院血液内科,西安 710038空军军医大学唐都医院血液内科,西安 710038
淋巴瘤化疗焦虑抑郁变化轨迹影响因素
lymphomachemotherapyanxietydepressiontrajectory of changesinfluencing factors
《转化医学杂志》 2026 (6)
917-922,6
国家自然科学基金青年项目(82200171)中国人民解放军空军军医大学第二附属医院社会人才基金资助计划项目(2021SHRC065)
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