痛风性关节炎患者血清NF-κB和FGF-23表达水平及其临床意义OA
Expression Levels of Serum NF-κB and FGF-23 in Patients with Gouty Arthritis and Their Clinical Significance
目的 探讨痛风性关节炎(GA)患者血清核因子κB(NF-κB)、成纤维细胞生长因子23(FGF-23)表达水平及其临床意义.方法 选取2024年6月至2025年5月首都医科大学附属北京友谊医院收治的180例GA患者作为GA组,并依据疾病活动度分为急性期组(68例,急性发作期)与间歇期组(112例,间歇期);另选取同期189例健康体检者作为对照组.比较各组血清NF-κB、FGF-23水平.采用ROC曲线评估血清NF-κB、FGF-23水平对GA的诊断价值.进一步将单因素分析中有差异的变量纳入多因素Logistic逐步回归分析探讨GA的独立影响因素.结果 GA组血清NF-κB、FGF-23水平均高于对照组(P<0.05).急性期组血清NF-κB、FGF-23水平均高于间歇期组(P<0.05).ROC曲线显示,血清NF-κB、FGF-23及二者联合诊断GA的曲线下面积分别为0.752、0.783、0.917,血清NF-κB、FGF-23联合诊断的曲线下面积优于其各自单独诊断(Z=5.196,P<0.05;Z=7.034,P<0.05).GA组血尿酸、C反应蛋白、血肌酐水平及高血压比例均高于对照组(P<0.05).多因素Logistic逐步回归分析显示,高血压(OR=1.844,95%CI:1.141～2.981)、血尿酸(OR=2.232,95%CI:1.300～3.834)、NF-κB(OR=2.385,95%CI:1.583～3.592)、FGF-23(OR=2.349,95%CI:1.494～3.694)是影响GA的独立危险因素(P<0.05).结论 GA患者血清NF-κB与FGF-23水平明显升高,其变化与疾病活动程度密切相关,二者对GA具有良好的诊断价值,同时也是GA发病的独立危险因素.
Objective To investigate the serum expression levels of nuclear factor-κB(NF-κB)and fibroblast growth factor 23(FGF-23)in patients with gouty arthritis(GA)and their clinical significance.Methods A total of 180 patients with GA(n=180)admitted to Beijing Friendship Hospital,Capital Medical University from June 2024 to May 2025 were selected as the GA group and were further divided into the acute phase group(n=68)and the intercritical phase group(n=112)based on disease activity.Another 189 healthy physical examinees(n=189)in the same period were selected as the control group.The serum levels of NF-κB and FGF-23 were compared among the groups.Receiver Operating Characteristic(ROC)curve was used to analyze the diagnostic value of serum NF-κB and FGF-23 levels for GA.Variables with significant differences in the univariate analysis were included in the multivariate Logistic stepwise regression analysis to explore the independent influencing factors of GA.Results The serum levels of NF-κB and FGF-23 in the GA group were higher than those in the control group(P<0.05).The serum levels of NF-κB and FGF-23 in the acute phase group were higher than those in the intercritical phase group(P<0.05).ROC curve showed that the areas under the curves for serum NF-κB,FGF-23,and their combined diagnosis of GA were 0.752,0.783,and 0.917,respectively.The AUC for combined diagnosis was superior to single diagnosis of the two indicators alone(Z=5.196,P<0.05;Z=7.034,P<0.05).The levels of serum uric acid,C-reactive protein,serum creatinine and the proportion of hypertension patients in the GA group were higher than those in the control group(P<0.05).Multivariate Logistic stepwise regression analysis showed that hypertension(OR=1.844,95%CI:1.141-2.981),serum uric acid(OR=2.232,95%CI:1.300-3.834),NF-κB(OR=2.385,95%CI:1.583-3.592),and FGF-23(OR=2.349,95%CI:1.494-3.694)were independent risk factors for GA(P<0.05).Conclusion The serum NF-κB and FGF-23 levels in GA patients are significantly elevated,and their changes are closely related to disease activity.Both indicators have favorable diagnostic value for GA,and they are also independent risk factors for the onset of GA.
周航;张霞;王天琪;杨帆;刘慧兰;王磊
首都医科大学附属北京友谊医院风湿内科,北京 100050首都医科大学附属北京友谊医院风湿内科,北京 100050首都医科大学附属北京友谊医院风湿内科,北京 100050首都医科大学附属北京友谊医院风湿内科,北京 100050首都医科大学附属北京友谊医院风湿内科,北京 100050渭南市中心医院中医科,陕西渭南 714100
痛风性关节炎核因子κB成纤维细胞生长因子23诊断价值
gouty arthritisnuclear factor kappa-Bfibroblast growth factor 23diagnostic value
《转化医学杂志》 2026 (6)
901-905,5
中国老年学和老年医学会科研项目(CAGG2025156)
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