50岁以上骨质疏松性骨折患者血清尿酸与全身炎症反应指数的相关性OA

Objective To investigate the association between serum uric acid(SUA)and the systemic inflam-mation response index(SIRI)in elderly adults with osteoporotic fracture(OPF),and to explore the modifying role of body mass index(BMI)in this relationship.Methods This cross-sectional study included 2 279 hospitalized patients aged≥50 years with primary OPF admitted to Kunshan Hospital of Jiangsu University between January 2017 and July 2022.SUA was treated as the exposure variable and SIRI as the outcome variable.Covariates included demographic fac-tors,metabolic parameters,and hematological parameters.Generalized estimating equations(GEE)and generalized addi-tive models(GAM)were used to assess linear and nonlinear associations between SUA and SIRI.Stratified analyses and two-piecewise linear regression were performed based on BMI categories.Results SUA was significantly positively associ-ated with SIRI(β=0.528,95%CI:0.294-0.761,P＜0.001).This association was strongest in the BMI 24-28 kg/m2 group,with a clear threshold effect(P=0.001).When SUA levels were below the inflection point(415 μmol/L),SUA was positively correlated with SIRI;above this threshold,the association was attenuated.Conclusion There is a BMI-de-pendent nonlinear relationship between SUA and SIRI,suggesting its potential role as an indicator of inflammation risk.