基于"瘀热毒"理论探讨cGAS/STING 通路调控心肌梗死的机制OA

This study explores the role of the cGAS/STING pathway in the pathogenesis of myocardial Infarction(MI)based on the"stasis-heat-toxicity"theory in traditional Chinese medicine(TCM).TCM posits that"stasis-heat-toxicity"constitutes one of the key pathological factor triggering myocardial infarction.Blood stasis obstruction leads to stagnant heat transforming into toxins,with these three elements interacting through mutual promotion and transformation,thereby exacerbating disease progression.The cGAS/STING pathway plays a crucial role in the pathogenesis of myocardial infarction by modulating M1 macrophage polarization and mediating inflammatory responses.This mechanism closely aligns with the generation and dynamic transformation of stasis,heat,and toxicity,serving as their microscopic manifestation.Notably,TCM herbal interventions with heat-clearing,blood-activating,and toxin-resolving properties may attenuate inflammation by inhibiting the cGAS/STING pathway,suppress M1 macrophage polarization,improve cardiac function,and reduce Infarction size,thereby highlighting this pathway as a potential therapeutic target for MI.