microRNA调控卒中后认知损伤修复机制及中医药干预研究进展OA

Post-stroke cognitive impairment(PSCI)is one of the most common complications of stroke,seriously compromising quality of life and rehabilitation;it has become an urgent challenge in the field of stroke management.microRNAs(miRNAs)play pivotal regulatory roles in the pathological processes underlying PSCI,including inflammation,apoptosis,oxidative stress,autophagy,and synaptic plasticity.Traditional Chinese medicine(TCM)has shown unique advantages and prospects in PSCI treatment,exerting its effects through overall regulation,multi-component synergy,and multi-target modulation of miRNA-mediated mechanisms.This review systematically summarizes the mechanism of miRNA in improving cognitive impairment and repair after stroke,and highlights recent progress on TCM-based interventions targeting miRNAs in PSCI.The findings provide a reference for miRNAs as potential biomarkers and therapeutic targets,and offer a theoretical basis for advancing the modernization of TCM in PSCI management.