CREB介导的神经炎症在阿尔茨海默病中的研究进展OA
Research progress of CREB-mediated neuroinflammation in Alzheimer's disease
阿尔茨海默病(AD)是一种以认知衰退为特征的神经退行性疾病,神经炎症是其关键驱动因素.cAMP反应元件结合蛋白(CREB)作为重要转录因子,通过调控多条信号通路参与神经炎症、突触可塑性及神经元存活等过程.本文综述了 CREB的生物学功能(神经可塑性等),系统阐释了 CREB介导的cAMP/PKA、MAPK/ERK、PI3K/AKT等信号通路在AD介导的神经炎症中的调控机制,总结了小分子药物、天然化合物和cAMP类似物的CREB激动剂研究进展.靶向CREB的精准调控可能为AD治疗提供新策略,并为寻找新的AD治疗靶点和药物开发提供了理论依据.本文以CREB介导的神经炎症在AD中的研究进展进行综述.
Alzheimer's disease(AD)is a neurodegenerative disease characterized by cognitive decline,with neuroinflammation being a key driver.As an important transcription factor,cyclic AMP response element binding protein(CREB)is involved in neuroinflammation,synaptic plasticity,and neuronal survival through regulation of multiple signaling pathways.This article reviews the biological functions of CREB,systematically explains the regulatory mechanisms involved in CREB-mediated signaling pathways in AD related to neuroinflammation,including cAMP/PKA,MAPK/ERK,and PI3K/AKT,and summarizes the research progress on CREB agonists of small molecule drugs,natural compounds,and cAMP analogues.Precise CREB regulation may provide a new strategy for AD treatment and provide a theoretical basis for identifying new AD therapeutic targets and drugs.This article reviews the research progress of CREB-mediated neuroinflammation in AD.
马晨菘;黄艳丽;范茗越;张振强;谢治深;李中华
河南中医药大学中医药科学院,郑州 450046河南中医药大学中医药科学院,郑州 450046河南中医药大学中医药科学院,郑州 450046河南中医药大学中医药科学院,郑州 450046河南中医药大学中医药科学院,郑州 450046河南中医药大学中医药科学院,郑州 450046
医药卫生
阿尔茨海默病CREB神经炎症信号通路
Alzheimer's diseaseCREBneuroinflammationsignaling pathway
《中国比较医学杂志》 2026 (8)
97-106,10
国家自然科学基金项目(82274612)河南省科技研发计划联合基金(242301420019).
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