饮用水中硒摄入对健康影响的定性循证研究OA

[Objective]To systematically review the impact of selenium intake from drinking water on health.[Method]Using the search terms"water""selenium""health"and"disease"we searched for relevant Chinese and English literature published from January 1,2004,to July 1,2024,in seven databases:China National Knowledge Infrastructure(CNKI),Wanfang,China Biology Medicine disc(CBM),PubMed,and Embase.The literature was screened and assessed according to the inclusion and exclusion criteria.[Result]A total of 8285 articles were retrieved,and 11 articles were included as the main evidence for this review.Population stud-ies indicated that selenium deficiency was common in Kashin-Beck disease(KBD)endemic areas,where the selenium content in water was significantly lower than in non-endemic areas.Low-selenium water sources were more prevalent in these endemic areas,suggesting that selenium deficiency may be one of the important factors contributing to the development of KBD.Long-term consumption of water with higher concentrations of selenium was associated with the incidence of amyotrophic lateral sclerosis(ALS),with a stronger effect on women and a potential increase in the risk of certain cancers.In animal experiments,two studies explored the positive health effects of high-selenium water,while one study showed that exposure to high concentrations of selenium in water led to selenium accumulation in fish tissues,which had adverse effects on their growth.[Conclusion]Selenium levels in drinking water are associated with various health risks.Multiple guidelines recommend that selenium content in drinking water should not exceed 10-50 μg/L.As an essential nutrient,selenium is beneficial to health within a certain intake range,but excessive exposure must be avoided to prevent potential health risks.