植皮术联合外用重组人粒细胞巨噬细胞集落刺激因子凝胶治疗Ⅲ度烧伤创面疗效观察OA

Objective To explore the clinical effect of skin grafting combined with external use of Recombinant Human Granulocyte-macrophage Colony-stimulating Factor(rhGM-CSF)gel in the treatment of patients with third-degree burn wounds.Methods A total of 122 patients with third-degree burns admitted to the hospital from June 2022 to June 2024 were selected.Using random number table method,they were divided into the control group(61 cases treated with scab removal and skin grafting)and the observation group(61 cases treated with external use of rhGM-CSF in addition to the treatment in the control group).The Wound recovery indicators,Scar score[Vancouver Scar Scale(VSS)],inflammatory factor levels[C-reactive Protein(CRP),Procalcitonin(PCT),Interleukin-6(IL-6),pain factor levels[5-hydroxytryptamine(5-HT),substance P,β-endorphin(β-EP)]and complications were compared between the two groups.Results The granulation growth time,wound cleaning time,wound healing time,and hospitalization time in the observation group were shorter than those in the control group(P＜0.05).The wound healing rate of the observation group after 4 weeks of treatment was higher than that of the control group(P＜0.05).After treatment(7 days after skin grafting),CRP,PCT,IL-6,5-HT,and substance P in the observation group were lower than those in the control group,and β-EP was higher than that in the control group(P＜0.05).At 6 months after operation,the scar color,thickness,vascular distribution,and softness scores in the observation group were lower than those in the control group(P＜0.05).The total incidence of complications in the observation group was lower than that in the control group(P＜0.05).Conclusion Topical application of rhGM-CSF gel after skin grafting for treating third-degree burn wounds can effectively promote wound healing,improve the scar,and improve the levels of inflammatory and pain factors,with high safety.