烧伤患者血清细胞因子及淋巴细胞水平变化与烧伤程度和创面愈合的关系研究OA
Study on the Relationship between the Changes of Serum Cytokines and Lymphocytes in Burn Patients and the Degree of Burn and Wound Healing
目的:研究烧伤患者血清细胞因子及外周血淋巴细胞水平变化与烧伤程度和创面愈合的关系.方法:以2023年5月-2025年1月太原钢铁(集团)有限公司总医院收治的98例烧伤患者作为烧伤组,另选取同期于本院收治的98例经治疗后康复的烧伤瘢痕患者为对照组.测量计算烧伤组治疗2周后创面愈合率,比较两组血清细胞因子、外周血淋巴细胞水平及不同烧伤程度治疗前、治疗2周后患者血清细胞因子、外周血淋巴细胞水平,并分析烧伤患者血清细胞因子、外周血淋巴细胞水平与创面愈合的相关性.结果:烧伤组治疗2周后创面愈合率为(79.84±5.63)%.烧伤组血清沉默信息调节因子2相关酶1(Silent Mating Type Information Regulation 2 Homolog 1,SIRT1)、促红细胞生成素(Erythropoietin,EPO)、可溶性细胞间黏附分子-1(Soluble Intercellular Adhesion Molecule-1,sICAM-1)及外周血CD8+水平高于对照组,外周血CD4+水平、CD4+/CD8+低于对照组(P＜0.05).治疗前和治疗2周后,浅Ⅱ度组、深Ⅱ度组、Ⅲ度组血清SIRT1、EPO、sICAM-1及外周血CD8+水平呈升高趋势,外周血CD4+水平、CD4+/CD8+呈降低趋势(P＜0.05);治疗2周后浅Ⅱ度组、深Ⅱ度组、Ⅲ度组血清SIRT1、EPO、sICAM-1、外周血CD8+水平均低于治疗前,外周血CD4+水平、CD4+/CD8+高于治疗前(P＜0.05).血清SIRT1、EPO、外周血CD4+水平、CD4+/CD8+与创面愈合率呈正相关(r=0.637、0.718、0.627、0.619,P＜0.05),血清sICAM-1及外周血CD8+水平与创面愈合率呈负相关(r=-0.584、-0.498,P＜0.05).结论:血清SIRT1、EPO、sICAM-1及外周血淋巴细胞水平在烧伤及不同烧伤程度患者中存在明显差异,且其水平与患者创面愈合情况密切相关.
Objective To study the relationship between the changes of serum cytokines and lymphocytes in burn patients and the degree of burn and wound healing.Methods 98 burn patients admitted to the General Hospital of Taiyuan Iron and Steel(Group)Co.,Ltd.from May 2023 to January 2025 were selected as the burn group,and the clinical data of 98 healthy burn scar patients admitted to the hospital during the same period were selected as the control group.The wound healing rate of burn patients after 2 weeks of treatment was counted.The levels of serum cytokines and peripheral blood lymphocytes were compared between the two groups,and the levels of serum cytokines and peripheral blood lymphocytes before and after treatment for 2 weeks in patients with different degrees of burn were compared.The correlation between serum cytokines,peripheral blood lymphocyte levels and wound healing in burn patients was analyzed.Results The wound healing rate of the burn group was(79.84±5.63)%after 2 weeks of treatment.The levels of Silent Mating Type Information Regulation 2 Homolog 1(SIRT1),Erythropoietin(EPO),Soluble Intercellular Adhesion Molecule-1(sICAM-1)and peripheral blood CD8+in the burn group were higher than those in the control group,while the levels of peripheral blood CD8+and CD4+/CD8+were lower than those in the control group(P＜0.05).Before treatment and after 2 weeks of treatment,the levels of serum SIRT1,EPO,sICAM-1 and peripheral blood CD8+in shallow II degree group,deep II degree group and III degree group showed an increasing trend,while the levels of peripheral blood CD4+and CD4+/CD8+showed a decreasing trend(P＜0.05).After 2 weeks of treatment,the levels of serum SIRT1,EPO,sICAM-1 and peripheral blood CD8+in the superficial II degree group,deep II degree group and III degree group were lower than those before treatment,and the levels of peripheral blood CD4+and CD4+/CD8+were higher than those before treatment(P＜0.05).Serum SIRT1,EPO,peripheral blood CD4+level and CD4+/CD8+were positively correlated with wound healing rate(r=0.637,0.718,0.627,0.619,P＜0.05).Serum levels of sICAM-1 and peripheral blood CD8+were negatively correlated with wound healing rate(r=-0.584,-0.498,P＜0.05).Conclusion The levels of serum SIRT1,EPO,sICAM-1 and peripheral blood lymphocytes in patients with burns and different degrees of burns are significantly different,and their levels were closely related to the wound healing of patients.
胡冰;郭万里;段鹏;成剑
太原钢铁(集团)有限公司总医院烧伤科 山西 太原 030003太原钢铁(集团)有限公司总医院烧伤整形与创面修复中心 山西 太原 030003太原钢铁(集团)有限公司总医院烧伤科 山西 太原 030003太原钢铁(集团)有限公司总医院烧伤科 山西 太原 030003
医药卫生
烧伤细胞因子淋巴细胞创面愈合
burncytokineslymphocytewound healing
《中国美容医学》 2026 (6)
26-30,5
2024年度山西省高等学校科技创新项目(编号:2024L116)
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