非小细胞肺癌动态18F-FDG PET/CT参数Ki与病理特征的相关性研究OA

Objective:To compare the correlation differences between dynamic PET parameter Ki and pathological features in non-small cell lung cancer(NSCLC),evaluate the application value of Ki compared to SUVmax,and explore its potential prognostic value.Methods:A retrospective analysis was conducted on 221 newly diagnosed NSCLC patients who underwent 18F-FDG PET/CT dynamic imaging with pathological confirmation.Differences in Ki and SUVmax between different pathological features(histological subtype,differentiation grade,EGFR,PD-L1,and Ki-67 expression)were compared.Statistical significance was set at P<0.05.Results:The Ki and SUVmax of the squamous cell carcinoma(SCC)group(n=38)were significantly higher than those of the adenocarcinoma(AC)group(n=168)(all P<0.05).Poorly differentiated tumors(n=85)showed elevated Ki and SUVmax compared to moderately/well-differentiated tumors(n=77)(all P<0.05).The Ki of EGFR-mutant group(n=49)was lower than that of wild-type group(n=34)(P<0.05),and the difference in SUVmax was not statistically significant(P>0.05).PD-L1-posi-tive tumors(n=85)demonstrated higher Ki and SUVmax than PD-L1-negative tumors(n=64)(all P<0.05).Ki-67-high tumors(n=28)exhibited significantly greater Ki and SUVmax than Ki-67-low tumors(n=24)(all P<0.05),with Ki showing stronger correla-tion with Ki-67(r=0.601 vs 0.501,all P<0.05).Conclusion:The dynamic parameter Ki varies in different pathological features of NSCLC,indicating its potential prognostic value in NSCLC.