DCE-MRI定量参数对乳腺癌患者的预测效能及与血管生成素2、血管内皮生长因子的相关性OA

Objective:To analyze the predictive efficacy of DCE-MRI quantitative parameters in breast cancer patients and their correlation with angiopoietin 2 and vascular endothelial growth factor.Methods:A total of 130 breast cancer patients treated in our hospital from April 2022 to April 2025 were selected as the disease group,and 110 healthy volunteers of the same period and age were selected as the control group.The quantitative parameters of DCE-MRI in the two groups and in different clinical stages of breast cancer were compared.The predictive efficacy of DCE-MRI quantitative parameters for breast cancer patients was analyzed by constructing receiver operating characteristic(ROC)curves.Results:Compared with the control group,vascular endothelial growth factor,Ve,Ktrans,angiopoietin 2,and Kep were increased in the disease group(P<0.05).Compared with stage Ⅰ,vascular endothelial growth factor,Ve,Ktrans,angiopoietin 2,and Kep were increased in stagesⅡ,Ⅲ,and Ⅳ;compared with stage Ⅱ,vascular endothelial growth factor,Ve,Ktrans,angiopoietin 2,and Kep were increased in stages Ⅲ and Ⅳ;compared with stage Ⅲ,vascular endothelial growth factor,Ve,Ktrans,and angiopoietin 2 in stage Ⅳ,Kep were increased significantly(P<0.05).Pearson correlation analysis showed that Ve,Ktrans,and Kep were positively correlated with angiopoietin 2 and vascular endothelial growth factor(P<0.05).The ROC curves indicated that the predictive efficacy of the combined test of Ve,Ktrans,and Kep was higher than that of the single prediction(P<0.05).Conclusion:Ve,Ktrans,and Kep are increased in breast cancer patients and positively correlated with angiopoietin-2 and vascular endothelial growth factor levels.Concurrently,the combined detection of Ve,Ktrans,and Kep demonstrates high predictive efficacy for breast cancer.Clinically,DCE-MRI examinations of breast cancer patients can provide reference for clinical preliminary assessment of disease status and subsequent treatment.