颅脑超声与肌酸激酶同工酶联合检测在新生儿颅内出血诊断中的应用价值研究OA

Objective:To explore the application value of combined detection of cranial ultrasound(CUS)and creatine ki-nase isoenzyme(CK-MB)in the diagnosis of intracranial hemorrhage(ICH)in neonates.Methods:It included 42 neonates diag-nosed with ICH through CT/MRI examination in our hospital from January 2020 to December 2024 as the observation group retrospectively.Another 41 neonates without ICH in our hospital during the same period were selected as the control group.Both groups underwent CUS and CK-MB tests.The parameters of the middle cerebral artery and CK-MB levels were com-pared between two groups of newborns,and the number of detected cases,detection rates,and diagnostic efficacy of CUS,CK-MB test,and combined test for ICH patients were compared in the observation group.Results:The number of cases di-agnosed by CUS was 33,with 9 missed diagnoses.The number of cases diagnosed by CK-MB was 31,with 11 missed diag-noses.Compared with the control group,the observation group had lower peak systolic velocity(PSV)parameters and higher re-sistance index(RI)parameters and CK-MB levels,and the differences were statistically significant(P<0.05).The detection rate of the combined CUS and CK-MB test in the observation group was 85.71%,which was higher than the detection rate of CUS(78.57%)and CK-MB(73.81%),but there was no significant difference(P<0.05).Compared with the single diagnosis of CUS and CK-MB,the combined test had a higher diagnostic value for ICH,and the difference was statistically significant(P<0.05).The combined test had the largest area under the curve(AUC)for ICH,which was 0.937,and the sensitivity was 0.857.Con-clusion:The diagnostic efficacy of combined detection of CUS and CK-MB in ICH diagnosis is significantly superior to that of single-item detection.It can provide a basis for early diagnosis and intervention.