盐酸戊乙奎醚在宫腔镜手术麻醉中的应用研究OA

Objective To explore the application effect and safety of penehyclidine hydrochloride in patients undergoing gynecological hysteroscopic surgery.Methods A total of 80 patients undergoing hysteroscopic surgery in Maternity&Child Care Center of Huaibei were retrospectively enrolled from January 2023 to March 2024,who were divided into the observation group(n=43)and the control group(n=37)according to different anesthesia regimens.Patients in the observation group were intravenously injected with penehyclidine hydrochloride before anesthesia induction,while patients in the control group were not given any treatment before anesthesia induction.The changes of vital sign indicators such as heart rate(HR),mean arterial pressure(MAP),and pulse oxygen saturation(SpO2)before anesthesia induction(T0),immediately after cervical dilation(T1),during surgery(T2),at the end of surgery(T3),immediately after anesthesia recovery(T4),and intraoperative dosage of propofol,awaking time and the incidence of adverse reactions were compared between the two groups of patients.Results The HR at T1 and T2,MAP at T1 to T3,and SpO2 at T1 to T4 of patients in the observation group were all higher than those in the control group(P<0.05).The intraoperative dosage of propofol of patients in the observation group was lower than that in the control group(P<0.05),and awaking time was shorter than that in the control group(P<0.05).The incidence of intraoperative sinus bradycardia and the incidence of nausea and vomiting during anesthesia recovery period in the observation group were lower than those in the control group(P<0.05).Conclusion Penehyclidine hydrochloride applied in gynecological hysteroscopic surgery can effectively maintain stability of patients'vital signs,reduce the dosage of propofol,shorten the awaking time,with low incidence of adverse reactions and high safety.