STING1 negatively regulates translation and replication of foot-and-mouth disease virus independently of interferon and is antagonized by the viral proteins 3C and 2BOA
STING1 negatively regulates translation and replication of foot-and-mouth disease virus independently of interferon and is antagonized by the viral proteins 3C and 2B
Wenhua Shao;Zongsheng Zhao;Fan Yang;Zixiang Zhu;Haixue Zheng;Wei Zhang;Zhitong Chen;Tingting Zhou;Xiaoyi Zhao;Hongyi Liu;Chuangwei Chen;Xingyan Dong;Weijun Cao
College of Animal Science and Technology,Shihezi University,Shihezi 832001,China||State Key Laboratory of Animal Disease Control and Prevention,College of Veterinary Medicine,Lanzhou University,Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou 730000,ChinaCollege of Animal Science and Technology,Shihezi University,Shihezi 832001,ChinaState Key Laboratory of Animal Disease Control and Prevention,College of Veterinary Medicine,Lanzhou University,Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou 730000,ChinaState Key Laboratory of Animal Disease Control and Prevention,College of Veterinary Medicine,Lanzhou University,Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou 730000,ChinaState Key Laboratory of Animal Disease Control and Prevention,College of Veterinary Medicine,Lanzhou University,Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou 730000,ChinaState Key Laboratory of Animal Disease Control and Prevention,College of Veterinary Medicine,Lanzhou University,Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou 730000,ChinaState Key Laboratory of Animal Disease Control and Prevention,College of Veterinary Medicine,Lanzhou University,Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou 730000,ChinaState Key Laboratory of Animal Disease Control and Prevention,College of Veterinary Medicine,Lanzhou University,Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou 730000,ChinaState Key Laboratory of Animal Disease Control and Prevention,College of Veterinary Medicine,Lanzhou University,Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou 730000,ChinaState Key Laboratory of Animal Disease Control and Prevention,College of Veterinary Medicine,Lanzhou University,Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou 730000,ChinaState Key Laboratory of Animal Disease Control and Prevention,College of Veterinary Medicine,Lanzhou University,Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou 730000,ChinaState Key Laboratory of Animal Disease Control and Prevention,College of Veterinary Medicine,Lanzhou University,Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou 730000,ChinaState Key Laboratory of Animal Disease Control and Prevention,College of Veterinary Medicine,Lanzhou University,Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou 730000,China
Foot-and-mouth disease virus(FMDV)STING13C proteaseInterferon-independentAntiviral activity
Foot-and-mouth disease virus(FMDV)STING13C proteaseInterferon-independentAntiviral activity
《中国病毒学》 2026 (2)
355-370,16
We thank our laboratory members who helped us improve the manuscript with their technical assistance and invaluable suggestions.This work was supported by the National Key Research and Develop-ment Program of China(No.2021YFD1800300 to FY),the National Natural Science Foundation of China of China(32473064 to WZ),the Fundamental Research Funds for the Central Universities,the Scientific Funds of Gansu Province(23JRRA547 to WJC),the Science and Tech-nology Major Project of Gansu Province(No.22ZD6NA001 to HXZ),the Joint Research Foundation of Gansu Province(No.25JRRA1088,24JRRA804,No.24JRRA813 to FY),the Gansu Province Research-Production Integration Technology Breakthrough Empowerment Plan(25FNNA002 to HXZ),the Earmarked Fund(CARS-35 to HXZ),and the Strategic Priority Research Program of the National Center of Technol-ogy Innovation for Pigs(No.NCTIP-XD/C03 to HXZ).The funders had no role in study design,data collection and analysis,decision to publish,or preparation of the manuscript.
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