Establishment of severe in vitro and in vivo infection models for coxsackievirus B4 and their application in identifying viral virulence determinantsOA
Establishment of severe in vitro and in vivo infection models for coxsackievirus B4 and their application in identifying viral virulence determinants
Haoyi Liu;Rong Zhou;Qian Liu;Wenkuan Liu;Xianglin Xuan;Bizhen Tang;Huan Wang;Li Zhang;Shuyan Qiu;Chuncong Mo;Xiao Li;Xingui Tian
State Key Laboratory of Respiratory Disease,National Clinical Research Center for Respiratory Disease,National Center for Respiratory Medicine,Joint International Research Laboratory of Respiratory Health,Guangdong Basic Research Center of Excellence for Respiratory Medicine,Guangzhou Institute of Respiratory Health,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510182,China||China-Portugal Artificial Intelligence and Public Health Technologies Joint Laboratory,Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Diseases,Guangdong Provincial Key Laboratory of Respiratory Disease Research,Guangzhou Medical University,Guangzhou 511436,ChinaState Key Laboratory of Respiratory Disease,National Clinical Research Center for Respiratory Disease,National Center for Respiratory Medicine,Joint International Research Laboratory of Respiratory Health,Guangdong Basic Research Center of Excellence for Respiratory Medicine,Guangzhou Institute of Respiratory Health,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510182,China||China-Portugal Artificial Intelligence and Public Health Technologies Joint Laboratory,Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Diseases,Guangdong Provincial Key Laboratory of Respiratory Disease Research,Guangzhou Medical University,Guangzhou 511436,ChinaScientific Research Center,The First Affiliated Hospital of Guangdong Pharmaceutical University,Guangdong Pharmaceutical University,Guangzhou 510062,ChinaState Key Laboratory of Respiratory Disease,National Clinical Research Center for Respiratory Disease,National Center for Respiratory Medicine,Joint International Research Laboratory of Respiratory Health,Guangdong Basic Research Center of Excellence for Respiratory Medicine,Guangzhou Institute of Respiratory Health,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510182,China||China-Portugal Artificial Intelligence and Public Health Technologies Joint Laboratory,Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Diseases,Guangdong Provincial Key Laboratory of Respiratory Disease Research,Guangzhou Medical University,Guangzhou 511436,ChinaScientific Research Center,The First Affiliated Hospital of Guangdong Pharmaceutical University,Guangdong Pharmaceutical University,Guangzhou 510062,ChinaScientific Research Center,The First Affiliated Hospital of Guangdong Pharmaceutical University,Guangdong Pharmaceutical University,Guangzhou 510062,ChinaScientific Research Center,The First Affiliated Hospital of Guangdong Pharmaceutical University,Guangdong Pharmaceutical University,Guangzhou 510062,China||Kunming Medical University Haiyuan College,Kunming 650106,ChinaState Key Laboratory of Respiratory Disease,National Clinical Research Center for Respiratory Disease,National Center for Respiratory Medicine,Joint International Research Laboratory of Respiratory Health,Guangdong Basic Research Center of Excellence for Respiratory Medicine,Guangzhou Institute of Respiratory Health,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510182,ChinaState Key Laboratory of Respiratory Disease,National Clinical Research Center for Respiratory Disease,National Center for Respiratory Medicine,Joint International Research Laboratory of Respiratory Health,Guangdong Basic Research Center of Excellence for Respiratory Medicine,Guangzhou Institute of Respiratory Health,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510182,ChinaState Key Laboratory of Respiratory Disease,National Clinical Research Center for Respiratory Disease,National Center for Respiratory Medicine,Joint International Research Laboratory of Respiratory Health,Guangdong Basic Research Center of Excellence for Respiratory Medicine,Guangzhou Institute of Respiratory Health,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510182,China||China-Portugal Artificial Intelligence and Public Health Technologies Joint Laboratory,Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Diseases,Guangdong Provincial Key Laboratory of Respiratory Disease Research,Guangzhou Medical University,Guangzhou 511436,ChinaState Key Laboratory of Respiratory Disease,National Clinical Research Center for Respiratory Disease,National Center for Respiratory Medicine,Joint International Research Laboratory of Respiratory Health,Guangdong Basic Research Center of Excellence for Respiratory Medicine,Guangzhou Institute of Respiratory Health,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510182,China||China-Portugal Artificial Intelligence and Public Health Technologies Joint Laboratory,Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Diseases,Guangdong Provincial Key Laboratory of Respiratory Disease Research,Guangzhou Medical University,Guangzhou 511436,ChinaState Key Laboratory of Respiratory Disease,National Clinical Research Center for Respiratory Disease,National Center for Respiratory Medicine,Joint International Research Laboratory of Respiratory Health,Guangdong Basic Research Center of Excellence for Respiratory Medicine,Guangzhou Institute of Respiratory Health,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510182,China||China-Portugal Artificial Intelligence and Public Health Technologies Joint Laboratory,Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Diseases,Guangdong Provincial Key Laboratory of Respiratory Disease Research,Guangzhou Medical University,Guangzhou 511436,China
Coxsackievirus B4(CVB4)Severe infectionInfection modelNeurovirulenceViral virulence determinant
Coxsackievirus B4(CVB4)Severe infectionInfection modelNeurovirulenceViral virulence determinant
《中国病毒学》 2026 (2)
343-354,12
We thank Dr.Zheng Deng(Guangzhou Medical University,China)for helpful discussions and comments during manuscript preparation.We also thank Yinghua Zhou and Jing Ma for technical assistance.This study was supported by the National Science and Technology Major Project of China(2018ZX10102001).The funders had no role in the study design,data collection,data interpretation,or decision to submit the manuscript for publication.
评论