Two orthobunyaviruses:OYAV and EBIV co-opt the AhR-CYP1A1 axis to suppress type Ⅰ interferon responsesOA
Two orthobunyaviruses:OYAV and EBIV co-opt the AhR-CYP1A1 axis to suppress type Ⅰ interferon responses
Qianyun Hu;Fei Wang;Xiaoyu Wang;Xiaokui Li;Zhiming Yuan;Maohua Zhong;Han Xia
Key Laboratory of Virology and Biosafety,Wuhan Institute of Virology,Chinese Academy of Sciences,Wuhan 430071,China||University of Chinese Academy of Sciences,Beijing 100049,ChinaKey Laboratory of Virology and Biosafety,Wuhan Institute of Virology,Chinese Academy of Sciences,Wuhan 430071,ChinaKey Laboratory of Virology and Biosafety,Wuhan Institute of Virology,Chinese Academy of Sciences,Wuhan 430071,China||University of Chinese Academy of Sciences,Beijing 100049,ChinaKey Laboratory of Virology and Biosafety,Wuhan Institute of Virology,Chinese Academy of Sciences,Wuhan 430071,China||University of Chinese Academy of Sciences,Beijing 100049,ChinaKey Laboratory of Virology and Biosafety,Wuhan Institute of Virology,Chinese Academy of Sciences,Wuhan 430071,China||University of Chinese Academy of Sciences,Beijing 100049,ChinaInstitute of Infection,Immunology and Tumor Microenvironment,Hubei Province Key Laboratory of Occupational Hazard Identification and Control,Medical College,Wuhan University of Science and Technology,Wuhan 430065,ChinaKey Laboratory of Virology and Biosafety,Wuhan Institute of Virology,Chinese Academy of Sciences,Wuhan 430071,China||Institute of Infection,Immunology and Tumor Microenvironment,Hubei Province Key Laboratory of Occupational Hazard Identification and Control,Medical College,Wuhan University of Science and Technology,Wuhan 430065,China||Hubei Jiangxia Laboratory,Wuhan 430200,China
OrthobunyavirusCytochrome P450 1A1(CYP1A1)Type Ⅰ interferon(IFN-Ⅰ)Aryl hydrocarbon receptor(AhR)Immune evasion
OrthobunyavirusCytochrome P450 1A1(CYP1A1)Type Ⅰ interferon(IFN-Ⅰ)Aryl hydrocarbon receptor(AhR)Immune evasion
《中国病毒学》 2026 (2)
329-342,14
We would like to express our gratitude to the Institutional Center for Shared Technologies and Facilities of Wuhan Institute of Virology,CAS.This work was supported by the National Key Research and Develop-ment Program of China(2023YFC2305900),and the Youth Program of Wuhan Institute of Virology(2023QNTJ-03).
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