EBV nuclear antigen 1 hijacks DDX5/BZLF1 axis to facilitate viral lytic replicationOA
EBV nuclear antigen 1 hijacks DDX5/BZLF1 axis to facilitate viral lytic replication
Li Yang;Jianhong Lu;Shuyu Xin;Shen Li;Pengfei Cao;Zeyu Sun;Mingjuan Jiang;Yujie Xin;Xiaoling Su;Jing Yang
Department of Medical Microbiology,Xiangya School of Basic Medical Sciences,Central South University,Changsha 410013,China||Key Laboratory of Cancer Carcinogenesis and Invasion of Chinese Ministry of Education,NHC Key Laboratory of Carcinogenesis,Central South University,Changsha 410078,ChinaDepartment of Medical Microbiology,Xiangya School of Basic Medical Sciences,Central South University,Changsha 410013,China||Key Laboratory of Cancer Carcinogenesis and Invasion of Chinese Ministry of Education,NHC Key Laboratory of Carcinogenesis,Central South University,Changsha 410078,China||Department of Microbiology,School of Basic Medical Sciences,Xinjiang Medical University,Urumqi 830017,ChinaDepartment of Medical Microbiology,Xiangya School of Basic Medical Sciences,Central South University,Changsha 410013,China||Key Laboratory of Cancer Carcinogenesis and Invasion of Chinese Ministry of Education,NHC Key Laboratory of Carcinogenesis,Central South University,Changsha 410078,ChinaDepartment of Medical Microbiology,Xiangya School of Basic Medical Sciences,Central South University,Changsha 410013,China||Key Laboratory of Cancer Carcinogenesis and Invasion of Chinese Ministry of Education,NHC Key Laboratory of Carcinogenesis,Central South University,Changsha 410078,ChinaKey Laboratory of Cancer Carcinogenesis and Invasion of Chinese Ministry of Education,NHC Key Laboratory of Carcinogenesis,Central South University,Changsha 410078,ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases,National Clinical Research Center for Infectious Diseases,The First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310003,ChinaDepartment of Medical Microbiology,Xiangya School of Basic Medical Sciences,Central South University,Changsha 410013,China||Key Laboratory of Cancer Carcinogenesis and Invasion of Chinese Ministry of Education,NHC Key Laboratory of Carcinogenesis,Central South University,Changsha 410078,ChinaDepartment of Medical Microbiology,Xiangya School of Basic Medical Sciences,Central South University,Changsha 410013,China||Key Laboratory of Cancer Carcinogenesis and Invasion of Chinese Ministry of Education,NHC Key Laboratory of Carcinogenesis,Central South University,Changsha 410078,ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases,National Clinical Research Center for Infectious Diseases,The First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310003,ChinaDepartment of Medical Microbiology,Xiangya School of Basic Medical Sciences,Central South University,Changsha 410013,China||Key Laboratory of Cancer Carcinogenesis and Invasion of Chinese Ministry of Education,NHC Key Laboratory of Carcinogenesis,Central South University,Changsha 410078,China
Epstein-Barr virus(EBV)Epstein-Barr virus nuclear antigen 1(EBNA1)Dead-box helicase 5(DDX5)FL118Lytic replication
Epstein-Barr virus(EBV)Epstein-Barr virus nuclear antigen 1(EBNA1)Dead-box helicase 5(DDX5)FL118Lytic replication
《中国病毒学》 2026 (2)
314-328,15
We thank Prof.Sai Wah Tsao(The University of Hong Kong,Hong Kong SAR,China)and Prof.Xin Li(Shenzhen Hospital of Southern Medical University,Shenzhen,China)for providing the HONE1-EBV cell line.We are also grateful to Prof.Ronald N.Harty(University of Pennsylvania,Philadelphia,PA,USA)for providing the pCAGGS vector.Additionally,we acknowledge the Top-Notch Innovation Base of Basic Medicine,Central South University,for instrumental support with the inverted fluorescence microscope.This work was supported by the Na-tional Natural Science Foundation of China(82272981,32470171,82370612),the National Key Research and Development Program(2022YFA1303801),and the Zhejiang Provincial Natural Science Foundation of China(LTGC24C050002).
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