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Breaking barriers and beyond:Mechanisms and pathological implications of Zika virus traversal across blood-tissue interfacesOA

Breaking barriers and beyond:Mechanisms and pathological implications of Zika virus traversal across blood-tissue interfaces

Lixia Hui;Danyu Qian;Yulei Guo;Zhengjun Yi;Tao Guo;Aixin Li;Ying Wu

School of Laboratory Medicine,Shandong Second Medical University,Weifang 261053,ChinaSchool of Laboratory Medicine,Shandong Second Medical University,Weifang 261053,ChinaSchool of Laboratory Medicine,Shandong Second Medical University,Weifang 261053,ChinaSchool of Laboratory Medicine,Shandong Second Medical University,Weifang 261053,ChinaSchool of Basic Medical Sciences,Shandong Second Medical University,Weifang 261053,ChinaSchool of Laboratory Medicine,Shandong Second Medical University,Weifang 261053,ChinaState Key Laboratory of Virology and Biosafety and Hubei Province Key Laboratory of Allergy and Immunology,Institute of Medical Virology,TaiKang Medical School(School of Basic Medical Sciences),Wuhan University,Wuhan 430071,China

Zika virus(ZIKV)Blood-tissue barriersBarrier traversal mechanismsOrgan-specific pathologyMulti-organ tropism

Zika virus(ZIKV)Blood-tissue barriersBarrier traversal mechanismsOrgan-specific pathologyMulti-organ tropism

《中国病毒学》 2026 (2)

247-260,14

This work was supported by the National Natural Science Foundation of China(grant numbers 32500138,32122008 and 82472277),the Natural Science Foundation of Shandong Province(grant numbers ZR2023QH354 and ZR2022QH126)and the Domestic Visiting Scholar Program of the Shandong Provincial Department of Education(grant numbers 20256-01)and the National College Student Innovation and Entrepreneurship Training Program of Shandong Second Medical Uni-versity(202510438015).

10.1016/j.virs.2026.03.014

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