桑黄硒多糖对甲基硫氧嘧啶诱导小鼠肝损伤的保护作用OA

The aim of this experiment is to investigate the protective effect and potential mechanism of Sanghuang selenium polysaccharide(SHXDT)on a mouse liver injury model induced by methylthiouracil(MTU).The experiment randomly divided the mice into 5 groups,namely the normal control group(NC),the model group,and the low,medium,and high dose groups(SHXDT).The model group and each treatment group of mice were intraperitoneally injected with MTU to create a liver injury model,while the normal control group was injected with an equal amount of physiological saline.After 3 weeks of continuous treatment,the levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),total bilirubin(TBIL)in the serum of mice were measured to evaluate the degree of liver damage;Measure the content of malondialdehyde(MDA),superoxide dismutase(SOD),and glutathione peroxidase(GSH-Px)activity in liver tissue to assess oxidative stress levels;Observe the pathological changes of liver tissue through hematoxylin eosin(HE)staining.The results showed that compared with the model group,the serum ALT,AST,and TBIL levels of mice in each dose group of SHXDT were significantly reduced;The activities of SOD and GSH-Px also significantly decreased;The pathological damage to the liver has been improved.Conclusion:SHXDT has a significant protective effect on MTU induced liver injury in mice.