犬脂肪间充质基质细胞来源外泌体于宠物医疗的研究进展OA

Canine adipose-derived mesenchymal stromal cell-exosomes(cAD-MSC-Exos),as biologically significant extracellular vesicles enriched with bioactive molecules(e.g.,nucleic acids,proteins,and lipids),stand out for their low immunogenicity,high stability,and cross-species therapeutic compatibility.They have become a research focus in veterinary medicine due to their unique therapeutic potential.With advances in engineered exosome modification,targeted delivery technologies,and the integration of artificial intelligence with biomaterials,cAD-MSC-Exos applications have demonstrated preliminary efficacy and are expected to drive innovation in the veterinary medical market.However,clinical translation remains constrained by underdeveloped large-scale production techniques,insufficient mechanistic understanding,and the absence of unified quality evaluation standards.Therefore,comprehensive investigation into the biological properties,mechanisms of action,isolation techniques,and clinical applications of cAD-MSC-Exos is essential to provide technical guidance for veterinary cell-based therapies.