乳腺癌细胞增殖核抗原Ki-67表达与肿瘤浸润淋巴细胞相关性的系统评价与Meta分析OA

Objective To systematically review the correlation between cell proliferation nuclear antigen Ki-67 expression and tumor-infiltrating lymphocytes(TILs)level in breast cancer.Methods PubMed,Embase and Web of Science databases were systematically searched to collect studies on the correlation between Ki-67 expression level and TILs level in breast cancer from inception to November 30,2025.Two researchers independently screened literature,extracted data and assessed the risk of bias of included studies.Meta-analysis was performed using RevMan 5.4 software and Stata 17.0 software.Results A total of 31 studies involving 13,633 patients with breast cancer were included.Meta-analysis results showed that the proportion of patients with high levels of TILs in the Ki-67 high-expression group was significantly higher than that in the Ki-67 low-expression group[RR=2.02,95％CI(1.73,2.36),P<0.001].Subgroup analysis showed that the positive correlation between Ki-67 expression level and TILs level remained consistent with the overall Meta-analysis results across different subgroups,including different TILs subtypes,study populations,and sample sizes.Sensitivity analysis indicates that the results of the overall findings of the Meta-analysis was robust.Conclusion Current evidence shows that the TILs level is significantly positively correlated with Ki-67 expression level in breast cancer.This finding suggests that the proliferation activity of breast cancer cells may be closely associated with immune activation in the tumor microenvironment,but the above conclusion needs to be verified by more high-quality studies.