甘油三酯-葡萄糖-体重指数与抑郁的关联性研究:基于宜昌市农村心血管-肾脏-代谢综合征人群的横断面研究OA

Objective To investigate the association between triglyceride-glucose-body mass index(TyG-BMI)and depressive symptoms in individuals with cardiovascular-kidney-metabolic(CKM)syndrome,and its heterogeneity across different stages.Methods This study utilized data from a survey on comorbidities among adults in rural communities in Yichang of Hubei province,conducted in August 2023.Participants diagnosed with CKM sundrome were grouped according to baseline TyG-BMI levels.Depressive symptoms were assessed using the Patient Health Questionnaire-9(PHQ-9).Logistic regression was employed to analyze the association between TyG-BMI and depressive symptoms,followed by stratified analysis by age,sex,education level,smoking/alcohol status,and CKM syndrome stage.Restricted cubic spline(RCS)models were used to assess nonlinear relationships.Results A total of 2,089 patients with CKM sundrome stages 0-3 were included.The mean age of participants was(57.0±10.4)years,with 50.8％being female.After full adjustment for confounding factors,each 10-unit increase in TyG-BMI was associated with a 4.9％reduction in depression risk[OR=0.951,95％CI(0.903,0.999)].Subgroup analysis showed that this negative association was more significant in individuals aged≥60 years[OR=0.989,95％CI(0.980,0.998)]and those at CKM syndrome stage 0[OR=0.978,95％CI(0.961,0.996)].RCS model analysis showed a significant nonlinear relationship trend between TyG-BMI and depression symptoms.Conclusion The higher TyG-BMI levels were associated with a lower prevalence of depressive symptoms among individuals with CKM syndrome stages 0-3,and this association was more pronounced in metabolically healthy individuals(CKM syndrome stage 0)and individuds aged≥60 years.Nonlinear analysis suggests that moderate levels of TyG-BMI may have neuroprotective effects.