电子烟油中丙帕酯和异丙帕酯的质谱鉴定分析OA
Identification of Propoxate and Isopropoxate in the Seized Electronic Cigarette Oil by Mass Spectrometry
本研究建立了基于气相色谱-质谱法(GC-MS)和超高效液相色谱-四极杆/静电场轨道高分辨质谱法(ultra performance liquid chromatography-quadrupole/orbitrap high resolution mass spectrometry,UPLC-Q/Orbitrap HRMS)鉴定可疑电子烟油中丙帕酯和异丙帕酯的方法.可疑的两种电子烟油经稀释过滤后使用GC-MS和UPLC-Q/Orbitrap HRMS方法分析,发现分别含有两种未知成分.通过采用EI-MS和Full MS/dd MS2两种质谱鉴定模式,其碎片信息与已知的依托咪酯类似;通过质谱解析,推断两种未知成分分别为丙帕酯和异丙帕酯.依据推测结果,购买标准品进行比对验证结果正确,并对检材中的异丙帕酯和丙帕酯进行定性定量检验.丙帕酯和异丙帕酯的检测限在GC-MS法中均为0.1 μg/mL,在UPLC-Q/Orbitrap HRMS法中均为0.1 ng/mL.在缺乏标准品的情况下,该方法为与依托咪酯相似的含有咪唑环的羧化酯类药物解析提供了一种快速、简便的筛查思路,适用于实际案件检验.
In this study,the methods for the identification of propoxate and isopropoxate in seized e-cigarette oil by gas chromatography-mass spectrometry(GC-MS)and ultra performance liquid chromatography-quadrupole/orbitrap high resolution mass spectrometry(UPLC-Q/Orbitrap HRMS)were established.Based on established methods,two unknown components were identified as propoxate and isopropoxate through structural analysis by MS and the characteristic fragment ions information acquired by EI-MS and Full MS/dd MS2 were similar to the known etomidate.The detection limits of propoxate and isopropoxate were both 0.1μg/mL for GC-MS and 0.1ng/mL for UPLC-Q/Orbitrap HRMS.This method provides a quick and simple approach for the identification of new carboxylate drugs with imidazole ring in the absence of standard substances and it could be applied to the analysis of actual cases.
林葭;曾文灿;林坚;叶树海;庄顺;黄建春
福建省公安厅鉴定中心,福州 350001福建省测试技术研究所,福州 350003福建省公安厅鉴定中心,福州 350001福建省公安厅鉴定中心,福州 350001福建省公安厅鉴定中心,福州 350001福建省公安厅鉴定中心,福州 350001
社会科学
丙帕酯异丙帕酯电子烟油气相色谱-质谱法高效液相色谱-高分辨质谱法裂解机制
propoxateisopropoxateelectronic cigarette oilGC-MSUPLC-HRMSfragmentation pathways
《刑事技术》 2026 (3)
239-245,7
福建省科技兴警科研专项(2024Y0071)
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