中医面舌特征的冠状动脉阻塞预警及其与心肌标志物的关系研究OA

Objective To explore whether digital facial and tongue diagnostic technologies can support the assessment of coronary heart disease(CHD)patients for coronary artery stenosis severity,and examine potential associations between digital tongue diagnosis features and myocar-dial biomarkers. Methods The TFDA-1 face and tongue diagnosis instrument and the TDAS analysis system were used to perform intelligent visual examination and analysis of the facial and tongue in CHD patients who attended the Department of Cardiology at Shanghai Baoshan Hospital of Integrated Traditional Chinese and Western Medicine between October 2,2023 and July 31,2024.Variables were screened using principal component analysis(PCA)and multicollineari-ty analysis to construct four machine learning models,including random forest,LightGBM,decision tree,and naive Bayes,for the early prediction of coronary artery stenosis severity.Model performance metrics,including sensitivity,specificity,precision,F1 score,accuracy,and the area under the receiver operating characteristic(ROC)curve(AUC),were evaluated.Visual analyses were performed using the SHapley Additive exPlanations(SHAP)interpreter and decision curve analysis.For patients after percutaneous coronary intervention(PCI),a conceptual model linking cardiac biomarkers and tongue diagnosis was constructed using the partial least squares structural equation modeling(PLS-SEM),and its validity was assessed. Results A total of 459 CHD patients were enrolled and assigned to a PCI group and a non-PCI group(which comprised two subgroups:mild stenosis or less group,moderate stenosis or greater group).For sublingual vein(SV)features,the PCI group had lower SV-a and SV-b than the other groups(P<0.01 and P<0.05,respectively).For tongue surface features,the PCI group had significantly higher tongue body(TB)-L,TB-a,and TB-b(P<0.05,P<0.01,and P<0.001,respectively),as well as higher tongue coating(TC)-a and TC-b(P<0.01 and P<0.001,respectively).Age,SV-a,SV-b,creatine kinase-myocardial band(CK-MB),CK,TC-a,lip-L,and lip-b were incorporated in the machine learning models.The random forest model per-formed best,with an AUC of 0.924,an F1 score of 0.839,precision of 0.807,accuracy of 0.864,sensitivity of 0.873,and specificity of 0.839.Decision curve analysis indicated that both Light-GBM and random forest had clinical utility.PLS-SEM confirmed the pathway relationships:myocardial biomarkers → TB and myocardial biomarkers → TC(coefficient=-0.238,t=2.239,P=0.025,and coefficient=-0.270,t=2.522,P=0.012,respectively). Conclusion This study developed a noninvasive early warning model for coronary artery stenosis in patients with CHD.It applied PLS-SEM to investigate the association between post-PCI cardiac biomarkers and tongue diagnosis,and validated the proposed association chain.These findings suggest that intelligent traditional Chinese medicine(TCM)visual diag-nosis integrated with modern digital technology may support CHD risk assessment and com-prehensive health management.