Box-Behnken响应面法优化伤筋止痛液体绷带OA

Objective To optimize the formulation of a liquid bandage for muscular fasciitis relief using the Box-Behnken response surface methodology.Methods Key factors including the pH of the boric acid-sodium hydroxide buffer solution,the amount of propylene glycol,the concentration of polyvinyl alcohol(PVA),and the concentration of water-soluble starch were investigated.A comprehensive evaluation system was constructed based on three indicators:adhesion performance,moisturizing properties,and crosslinking rate.Among them,adhesion was worth 40 points,moisturizing properties and crosslinking rate each 30 points,and the total score of comprehensive evaluation was 100 points.The Box-Behnken response surface methodology was used for experimental design,and multivariate regression analysis was conducted to optimize formulation parameters.Results The optimal formulation was determined as a buffer solution with pH 8.9,0.5 mL of propylene glycol,20%(w/v)PVA concentration,and 15%(w/v)water-soluble starch concentration.Under these conditions,the comprehensive score was 89.74 points.Conclusion The prepared liquid bandage exhibited moderate adhesion,good moisturizing properties,and rapid crosslinking.