基于"虚气留滞"理论探讨胃癌前病变的病机及论治OA
Exploring Pathogenesis and Treatment of Gastric Precancerous Lesions Based on Theory of"Qi Deficiency and Stagnation"
胃癌前病变(gastric precancerous lesions,GPL)是胃癌二级预防的重要环节.中医学认为,胃黏膜"炎-癌转化"是一个因虚生滞、滞而愈虚的动态变化过程.结合现代医学对GPL发生发展的病机认识,免疫功能下降与线粒体功能异常等可能为GPL"脾虚"的生物学基础,由此导致的炎症因子和代谢产物蓄积以及胃黏膜微循环障碍,形成了胃黏膜"炎-癌转化"的微观基础,从而加重胃黏膜炎症反应及黏膜损伤,促进"炎-癌转化"进展.本文基于GPL"虚气留滞"的病机演变规律,总结出"补虚通滞"的治疗原则,为GPL的临床诊疗提供思路.
Gastric precancerous lesions(GPL)are an important part of secondary prevention for gastric cancer.Traditional Chinese medicine believes that the inflammation-cancer transformation of the gastric mucosa is a dynamic process of deficiency leading to stagnation and deficiency worsening due to stagnation.According to the understanding of the pathogenesis of GPL in modern medicine,immune dysfunction and mitochondrial dysfunction may be the biological basis for spleen deficiency in GPL.The accumulation of inflammatory factors and metabolites,as well as microcirculatory disorders in the gastric mucosa,forms the microscopic basis for the inflammation-cancer transformation of the gastric mucosa,exacerbating the inflammatory response and damage of the gastric mucosa,and promoting the progression of inflammation-cancer transformation.This article summarized the therapeutic principles of tonifying deficiency and relieving stagnation based on the GPL pathogenesis evolution of qi deficiency and stagnation,providing ideas for the clinical diagnosis and treatment of GPL.
田依冰;温艳东;王阳;葛文通;杨治
中国中医科学院西苑医院,北京 100091中国中医科学院眼科医院,北京 100040中国中医科学院西苑医院,北京 100091中国中医科学院西苑医院,北京 100091中国中医科学院西苑医院,北京 100091
医药卫生
胃癌前病变"虚气留滞"免疫微环境线粒体自噬能量代谢发病机制补虚通滞
gastric precancerous lesionsqi deficiency and stagnationimmune microenvironmentmitochondrial autophagyenergy metabolismpathogenesistonifying deficiency and relieving stagnation
《世界中西医结合杂志》 2026 (4)
637-641,5
国家自然科学基金资助项目(82274509)首都卫生发展科研专项项目(首发2024-2-4184)中国中医科学院研究生科技创新项目(KC2025023)
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