双酚A对雄性大鼠生殖损伤及海龙黄精散的干预作用OA

Objective:To investigate the preventive effects of Hailong Huangjing powder on reproductive dam-age induced by bisphenol A(BPA)in male rats.Methods:SD male rats were used to establish a BPA-induced infertil-ity model.Different doses of Hailong Huangjing powder were administered for preventive and therapeutic interven-tions.Sperm quality,testicular histomorphology,oxidative stress levels,and cell apoptosis were evaluated in each group.Results:BPA exposure significantly reduced sperm progressive motility,total motility,and the percentage of normal sperm(P＜0.05),and caused marked testicular structural damage characterized by vacuolization,cell shed-ding,and decreased Sertoli cell numbers.BPA also reduced the activities of GSH-Px and CAT while increasing MDA levels(P＜0.05),accompanied by a notable increase in cell apoptosis(P＜0.05).Both preventive and therapeutic ad-ministration of Hailong Huangjing powder markedly improved BPA-induced reproductive injury,with the medium-and high-dose groups showing better efficacy.Conclusion:Hailong Huangjing powder effectively prevents and allevi-ates BPA-induced reproductive damage in male rats,and its mechanism may be related to enhancing antioxidant ca-pacity and regulating apoptosis of Sertoli cells.