不同脂耐量非肥胖男性高脂餐后血清皮质醇水平变化及其影响因素分析OA
Postprandial changes in serum cortisol levels after a high-fat meal and their influencing factors in non-obese men with different degrees of fat tolerance
目的 探讨不同脂耐量非肥胖男性在高脂餐后血清皮质醇水平的变化特点,并分析其影响因素.方法 选取90名非肥胖男性受试者,均接受口服脂肪耐量试验(OFTT),检测OFTT 0、2、4、6 h血清皮质醇、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、游离脂肪酸(FFA)及空腹血糖、空腹胰岛素(FINS).根据OFTT 0、4 h TG水平,将脂耐量分为脂耐量正常(NFT)、脂耐量减低(IFT)、高甘油三酯血症(HTG).比较不同脂耐量受试者血清皮质醇水平变化,采用单因素及多元线性回归分析血清皮质醇水平的影响因素.结果 90名受试者的脂耐量分别为NFT、IFT、HTG,各30名.同一脂耐量比较:所有受试者高脂餐后血清皮质醇及FFA水平均呈先降后升趋势,皮质醇于OFTT 4 h降至最低(P均<0.05),FFA于OFTT 2 h降至最低(P均<0.05),TG于OFTT 4 h达峰值(P均<0.05).不同脂耐量间比较:餐前,HTG受试者腰围、血清TG、TC、LDL-C、FFA及皮质醇水平均高于NFT、IFT受试者(P均<0.05).餐后各时间点,不同脂耐量受试者血清FFA、TG水平比较差异均有统计学意义(P均<0.05);OFTT 4 h,HTG受试者血清皮质醇水平高于NFT、IFT受试者(P均<0.05);OFTT 6 h,IFT、HTG受试者血清皮质醇水平均高于NFT受试者(P均<0.05).校正混杂因素后,餐前血清FFA、TG水平是同期血清皮质醇水平的独立影响因素(P均<0.05);OFTT 6 h血清FFA水平是同期血清皮质醇水平的独立影响因素(P<0.05).结论 脂耐量异常程度较重的非肥胖男性血清皮质醇水平更高,空腹血清FFA、TG水平及餐后6 h血清FFA水平是血清皮质醇水平的影响因素.
Objective To investigate postprandial changes in serum cortisol levels after a high-fat meal in non-obese men with different degrees of fat tolerance and to analyze the associated factors.Methods A total of 90 male par-ticipants underwent an oral fat tolerance test(OFTT).Based on fasting triglyceride(TG)levels and TG levels at OFTT 4 h,participants were classified into three groups(n=30 each):normal fat tolerance(NFT),impaired fat tolerance(IFT),and hypertriglyceridemia(HTG).All participants received a high-fat meal(1,500 kcal,with 60%of total ener-gy derived from fat).Blood samples were collected at OFTT 0,2,4,and 6 h,and serum cortisol,free fatty acids(FFA),TG,total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),fasting blood glucose,and fasting insulin(FINS)were measured.Multivariate linear regression analysis was performed to identify factors associated with cortisol levels.Results Within-group comparisons showed that cortisol and FFA levels decreased initially and then increased after the high-fat meal in all three groups.Cortisol levels reached their nadir at OFTT 4 h(all P<0.05),whereas FFA levels reached their lowest point at OFTT 2 h(all P<0.05).TG levels peaked at OFTT 4 h in all groups(all P<0.05).Between-group comparisons showed that,at baseline,waist circumfer-ence,TG,TC,LDL-C,FFA,and cortisol levels were significantly higher in the HTG group than in the NFT and IFT groups(all P<0.05).At all postprandial time points,significant differences were observed in FFA and TG levels among the three groups(all P<0.05).At OFTT 4 h,cortisol levels were significantly higher in the HTG group than in the NFT and IFT groups(all P<0.05).At OFTT 6 h,cortisol levels were significantly higher in the IFT and HTG groups than in the NFT group(all P<0.05).Multivariate linear regression analysis showed that,after adjustment for confounding fac-tors,preprandial FFA and TG levels were independent risk factors for cortisol levels(all P<0.05),whereas the FFA lev-el at OFTT 6 h was an independent risk factor for serum cortisol levels(P<0.05).Conclusion Serum cortisol levels were higher in non-obese men with more severe impairment of fat tolerance.Fasting FFA and TG levels,as well as serum FFA levels at 6 h postprandially,were independent risk factors for serum cortisol levels.
刘丹丹;任路平;刘晶;田培培;侯艺林;卢亚敏;唐雅乐;宋光耀
河北医科大学研究生学院,河北 石家庄 050017||河北省人民医院内分泌科,河北 石家庄 050051||保定市第一中心医院内分泌科,河北 保定 071000河北省代谢病重点实验室,河北 石家庄 050051河北省代谢病重点实验室,河北 石家庄 050051河北医科大学研究生学院,河北 石家庄 050017||河北省人民医院内分泌科,河北 石家庄 050051||沧州市中心医院内分泌科,河北 沧州 061000河北医科大学研究生学院,河北 石家庄 050017||河北省人民医院内分泌科,河北 石家庄 050051河北省人民医院核医学科,河北 石家庄 050051河北医科大学研究生学院,河北 石家庄 050017||河北省人民医院内分泌科,河北 石家庄 050051河北医科大学研究生学院,河北 石家庄 050017||河北省人民医院内分泌科,河北 石家庄 050051
医药卫生
脂耐量皮质醇游离脂肪酸高脂餐口服脂肪耐量试验男性
fat tolerancecortisolfree fatty acidshigh-fat mealoral fat tolerance testmale
《山东医药》 2026 (5)
38-43,6
国家自然科学基金项目(82170878).
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