婴儿期条栅视力与3岁神经发育的前瞻性队列研究OA

Objective:To explore the association between infant visual acuity and neurodevelopment at 3 years of age.Methods:We employed a prospective cohort study design.A total of 1 122 children from 1 096 families enrolled in the Jiangsu Birth Cohort between August 2016 and June 2019 were included.At 1 year of age,visual acuity was measured using the Teller Acuity Card Ⅱ.At 3 years of age,neurodevelopmental status was assessed using the Bayley Scales of Infant and Toddler Development,Version Ⅲ Screening Test,covering five domains:cognition,receptive communication,expressive communication,fine motor,and gross motor.Poisson regression models were used to examine the associations between infant visual acuity and neurodevelopment at 3 years of age.Results:Among the 1 122 children,94(8.4%)showed abnormal visual acuity.The prevalence of noncompetent neurodevelopment across five domains ranged from 3.5%to 10.3%.Compared with the group with normal visual acuity in infancy,the group with abnormal visual acuity had a 96%increased risk of being noncompetent development in gross motor domain at age 3(RR=1.96,95%CI 1.03-3.70).This association remained stable after excluding twins,preterm infants,low birth weight infantsand children conceived via assisted reproductive technology.Conclusion:Abnormal visual acuity in infancy was associated with an increased risk of being noncompetent in gross motor development at 3 years of age.