P2X7R和NLRP3炎性小体在炎症性皮肤病发病机制中的研究进展OA
Research progress on P2X7R and NLRP3 inflammasome in the pathogenesis of inflammato-ry skin diseases
P2X7受体(P2X7R)与NLRP3炎性小体共同构成了调控炎症反应的关键信号通路,在多种炎症性皮肤病中扮演重要角色.P2X7R被细胞外ATP激活后,通过离子跨膜信号介导NLRP3炎性小体的活化,进而驱动下游炎症反应.在不同疾病中,该通路呈现出异质性的调控模式,包括在银屑病中形成ATP-IL-23正反馈环路,在玫瑰痤疮中形成以LL-37为中心的多分子交互网络,以及在化脓性汗腺炎与白塞病中分别与IL-17/IL-1β和TNF-α建立正反馈放大机制.本文系统梳理P2X7R和NLRP3炎性小体在炎症性皮肤病中的作用机制与靶向治疗策略,以期为相关疾病的机制研究与治疗开发提供理论依据与转化视角.
The P2X7 receptor(P2X7R)and the NLRP3 inflammasome constitute a key signa-ling pathway in the regulation of inflammatory responses and play a critical role in various inflam-matory skin diseases.Upon activation by extracellular ATP,P2X7R mediates the activation of NL-RP3 inflammasome through transmembrane ion signaling,thereby driving downstream inflammatory responses.This pathway exhibits heterogeneous regulatory patterns across different diseases,inclu-ding the formation of an ATP-IL-23 positive feedback loop in psoriasis,a LL37-centered interac-tive network in rosacea,as well as positive feedback amplification involving IL-17/IL-1β in hidra-denitis suppurativa and TNF-α in Behçet's disease.This review systematically summarizes the mechanistic roles and targeted therapeutic strategies of P2X7R and NLRP3 in inflammatory skin disorders,aiming to provide a theoretical basis and translational perspective for further mechanistic research and therapeutic development.
陈华君;牛璐璐;蒙永霞;陈木开
中山大学附属第一医院,广东 广州 510080佛山市妇幼保健院,广东 佛山 528000中山大学附属第一医院,广东 广州 510080中山大学附属第一医院,广东 广州 510080
炎症性皮肤病P2X7受体NLRP3炎性小体
inflammatory skin diseasesP2X7 receptorNLRP3 inflammasome
《皮肤性病诊疗学杂志》 2026 (5)
388-396,9
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