CGF与Bio-Oss不同比例复合物引导颌骨再生的临床效果评价OA

Objective:To assess the clinical efficacy of different CGF(concentrated growth factor)and Bio-Oss bone meal composite ratios in guiding jawbone regeneration and determine the optimal ratio.Methods:Forty patients with jawbone cysts were divided into 4 groups.Composite materials were prepared with CGF and Bio-Oss at mass ratios of 1∶1(group A),2∶1(group B),4∶1(group C),and pure CGF(control group D),then implanted into bone cavities for regeneration.Follow-ups included imaging examinations and assessment of postoperative inflammation/swelling.Bone regeneration was evaluated at 3 and 6 months postoperatively.Results:At all observation time points,the average gray value of the residual bone cavity after jaw cyst surgery,bone regeneration in groups A,B,and C was significantly better than in group D(P<0.05).At 6 months,group B had significantly higher values than A,C(P<0.05).For inflammation/swelling,group B and C had lower indices than group A(P<0.05),group C lower than group B(P>0.05).Histological evaluations at 6 months postoperatively demon-strated nearly complete resorption of Bio-Oss bone graft particles,robust neo-osteogenesis and osteocyte formation,as well as dense,well-organized bone trabeculae with high osteogenic maturity.Conclusion:A CGF-to-Bio-Oss mass ratio of 2∶1 opti-mizes jawbone regeneration at 6 months,enhancing bone repair and accelerating patient recovery.