骨质疏松症患者血清CAV1、CYR61、HMGA2水平及对其发生骨折的预测价值OA

Objective To investigate the serum levels of caveolin-1(CAV1),cysteine-rich angiogenesis in-ducing factor 61(CYR61)and high mobility group A2(HMGA2)and their predictive value for fracture in pa-tients with osteoporosis(OP).Methods A total of 143 OP patients admitted to the hospital from January 2023 to May 2024 were selected as the study group,and were divided into non-fracture group and fracture group according to whether fracture occurred within 1 year.In addition,143 healthy people who underwent physical examination in the same hospital during the same period were selected as the control group.Baseline data of all subjects were collected.The levels of serum N-terminal procollagen type Ⅰ(PⅠNP),osteocalcin(BGP),C-terminal telopeptide of type I collagen(CTX),CAV1,CYR61 and HMGA2 were detected in all sub-jects.Bone mineral density(BMD)was measured and expressed as T value.Relative risk(RR)was used to e-valuate the relationship between OP patients with different levels of CAV1,CYR61,HMGA2 levels and frac-ture risk.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of ser-um CAV1,CYR61 and HMGA2 alone and in combination for fracture in OP patients.Pearson correlation was used to analyze the correlation between serum CAV1,CYR61,HMGA2 levels and bone mineral density in OP patients.Results The levels of CAV1,CYR61 and HMGA2 in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).There were 72 cases in the fracture group and 71 cases in the non-fracture group.The T value and serum PINP,BGP,CAV1,CYR61 and HMGA2 levels in the fracture group were lower than those in the non-fracture group,and the CTX level was higher than that in the non-fracture group,and the differences were statistically significant(P<0.05).The relative risk analysis showed that the risk of fracture in OP patients with low levels of CAV1,CYR61 and HMGA2 was higher than that in OP patients with high levels of CAV1,CYR61 and HMGA2.ROC curve analysis showed that the area under the curve(AUC)of CAV1,CYR61 and HMGA2 alone in predicting fracture in OP patients was 0.872,0.796 and 0.862 respectively.The AUC of the combination of CAV1,CYR61 and HM-GA2 in predicting fracture in OP patients(0.966)was greater than that of CAV1,Cyr61 and HMGA2 alone(Z=3.616,4.734,3.560,P<0.001).Pearson correlation analysis showed that the serum levels of CAV1,CYR61 and HMGA2 in OP patients were positively correlated with bone mineral density,PINP and BGP lev-els(P<0.05),and negatively correlated with CTX levels(P<0.05).Conclusion The serum levels of CAV1,CYR61 and HMGA2 in OP patients are decreased,which have certain predictive value for fracture oc-currence,and the combined predictive value of the three is higher.