血清Tim-1、CCL19对变应性鼻炎的诊断价值OA

Objective To investigate the diagnostic value of serum T lymphocyte immunoglobulin domain mucin domain-1(Tim-1)and CC chemokine ligand 19(CCL19)in allergic rhinitis(AR).Methods A total of 126 patients with AR who were diagnosed and treated in this hospital from May 2020 to July 2023 were select-ed as the AR group.According to the severity of the disease,the AR group was divided into mild group(41 ca-ses)and moderate to severe group(85 cases).Another 126 healthy people who underwent physical examina-tion in the hospital during the same period were selected as the control group.The serum levels of Tim-1 and CCL19 were detected in all subjects.Pearson correlation was used to analyze the correlation of serum Tim-1 and CCL19 levels with immune globulin(Ig)E level and score for allergic rhinits(SFAR)score,and the corre-lation between serum Tim-1 level and CCL19 level in AR patients.Multivariate Logistic regression was used to analyze the influencing factors of AR.The receiver operating characteristic(ROC)curve was drawn to ana-lyze the diagnostic value of serum Tim-1,CCL19 alone and combined detection for AR.Results The serum levels of Tim-1 and CCL19 in AR group were higher than those in control group,and the differences were sta-tistically significant(P<0.05).The serum levels of Tim-1 and CCL19 in the moderate to severe group were higher than those in the mild group,and the differences were statistically significant(P<0.05).The serum levels of Tim-1 and CCL19 in IgE positive AR patients with SFAR score≥7 were higher than those in IgE negative AR patients with SFAR score<7,and the differences were statistically significant(P<0.05).Pear-son correlation analysis showed that serum Tim-1 and CCL19 levels were positively correlated with IgE level and SFAR score(P<0.05),and serum Tim-1 level was positively correlated with CCL19 level(P<0.05).Multivariate Logistic regression analysis showed that increased levels of Tim-1 and CCL19 were independent risk factors for AR(P<0.05).The results of ROC curve analysis showed that the area under the curve(AUC)of Tim-1,CCL19 alone and in combination in the diagnosis of AR were 0.749,0.752 and 0.847 re-spectively.The AUC of combined diagnosis was greater than that of Tim-1 and CCL19 alone(Z=3.782,3.886,P<0.05).Conclusion The serum levels of Tim-1 and CCL19 in AR patients are increased,and are closely related to the severity of the disease,IgE level and SFAR score,suggesting that TIM-1 and CCL19 may be used as potential serological markers for auxiliary diagnosis of AR.