等离子射频消融术联合口服盐杜仲颗粒治疗腰椎间盘突出症的临床疗效OA

Objective To investigate the clinical efficacy of plasma radiofrequency ablation(RFA)com-bined with oral salt eucommia granules in the treatment of lumbar disc herniation(LDH).Methods A total of 208 patients with LDH admitted to this hospital from January 2022 to December 2024 were selected as the research objects,and they were divided into radiofrequency group(103 cases)and combined particle group(105 cases)by random number table method.The radiofrequency group was treated with low temperature RFA,and the combined granule group was treated with salt Eucommia granule on the basis of the radiofre-quency group.The clinical efficacy,pain degree,lumbar function and serological indexes[β-endorphin(β-EP),matrix metalloproteinase-3(MMP-3),prostaglandin E2(PGE2)]levels were compared between the two groups.The adverse reactions of the two groups during treatment were recorded.Results The total effective rate of the combined particle group was 98.10%,which was higher than 86.41%of the radiofrequency group,and the difference was statistically significant(P<0.05).After treatment,the visual analogue scale(VAS)score,serum MMP-3 and PGE2 levels of the two groups were lower than those before treatment,and the ser-um β-EP level was higher than that before treatment.The VAS score,serum MMP-3 and PGE2 levels of the combined granule group were lower than those of the radiofrequency group,and the serum β-EP level was higher than that of the radiofrequency group,the absolute value of VAS score and the difference of serum MMP-3,PGE2 and β-EP levels in the combined granule group were greater than those in the radiofrequency group,and the differences were statistically significant(P<0.05).After treatment,the serum levels of β-EP,subjective symptoms,clinical signs,JOA score and total score of activity limitation in both groups were higher than those before treatment,and those in the combined granule group were higher than those in the radiofre-quency group.The absolute values of the differences in the levels of β-EP,subjective symptoms,clinical signs,JOA score and total score of activity limitation in the combined granule group were greater than those in the radiofrequency group,the differences were statistically significant(P<0.05).During the treatment,no ad-verse reactions such as rashes or itching occurred in the two groups.Conclusion RFA combined with salt eu-commia granules can effectively reduce the patients'low back pain and leg pain,improve the patients'lumbar function,optimize MMP-3,PGE2,β-EP index levels,and improve the clinical efficacy.