急性脑梗死患者血清ITLN-1、DUSP1、KLF14水平与溶栓前NIHSS评分及静脉溶栓后血管再闭塞的关系OA

Objective To investigate the relationship between the levels of serum lectin-1(ITLN-1),dual specific phosphatase 1(DUSP1)and Krüpple-like transcription factor 14(KLF14)and the national institutes of health stroke scale(NIHSS)score before thrombolysis as well as vascular reocclusion after intravenous thrombolysis in patients with acute cerebral infarction(ACI).Methods A total of 172 patients with ACI ad-mitted to Zhangjiakou First Hospital from June 2021 to June 2025 were selected as the research objects.Ac-cording to whether vascular reocclusion occurred after thrombolysis,they were divided into non-reocclusion group and reocclusion group.The serum ITLN-1,DUSP1 and KLF14 levels of all subjects were detected,and the baseline data of all subjects were collected.Pearson correlation analysis was used to analyze the correlation between serum ITLN-1,DUSP1,KLF14 levels and NIHSS score before thrombolysis in ACI patients with vascular reocclusion.Multivariate Logistic regression was used to analyze the influencing factors of vascular reocclusion in patients with ACI.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of serum ITLN-1,DUSP1 and KLF14 alone and in combination for vascular reocclusion in pa-tients with ACI.Relative risk was used to analyze the relationship between serum ITLN-1,DUSP1,KLF14 levels and vascular reocclusion in patients with ACI.Results There were 130 patients in the non-reocclusion group and 42 patients in the reocclusion group.The NIHSS score before thrombolysis in the reocclusion group before thrombolysis was significantly higher than that in the non-reocclusion group(P<0.05).The serum levels of ITLN-1,DUSP1 and KLF14 in the reocclusion group were lower than those in the non-reocclusion group,and the differences were statistically significant(P<0.05).Pearson correlation analysis showed that serum ITLN-1,DUSP1,KLF14 levels were negatively correlated with NIHSS score before thrombolysis in ACI patients with vascular reocclusion(r=—0.486,—0.490,—0.473,P<0.05).Multivariate Logistic re-gression analysis showed that the increase of serum ITLN-1,DUSP1 and KLF14 levels were protective factors for vascular reocclusion in patients with ACI(P<0.05),and the increase of NIHSS score before thrombolysis was a risk factor for vascular reocclusion in patients with ACI(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of serum ITLN-1,DUSP1 and KLF14 for predicting vascular reocclusion in patients with ACI was 0.860,0.868 and 0.865 respectively.The AUC of combined detection of the three indi-cators for predicting vascular reocclusion in patients with ACI was 0.976.The AUC of combined detection of serum ITLN-1,DUSP1,and KLF14 was greater than that of individual prediction(Z=3.962,3.790,3.906,P<0.001).Relative risk analysis showed that the incidence of vascular reocclusion in ACI patients with high expression of serum ITLN-1,DUSP1,and KLF14 was 0.121,0.147,and 0.159 times higher than that in ACI patients with low expression of serum ITLN-1,DUSP1,and KLF14(P<0.05).Conclusion The serum levels of ITLN-1,DUSP1 and KLF14 in ACI patients are decreased,which are correlated with the NIHSS score be-fore thrombolysis ITLN-1,DUSP1 and KLF14 all have certain auxiliary predictive value for vascular reocclu-sion after intravenous thrombolysis.