IBI、SAA/hs-CRP比值对重症腺病毒肺炎患儿预后的影响OA

Objective To investigate the effects of inflammatory burden index(IBI)and serum amyloid A/high-sensitivity C reactive protein(SAA/hs-CRP)ratio on the prognosis of children with severe adenovirus pneumonia(SAdVP).Methods A total of 175 children with SAdVP admitted to Xi'an Union Hospital from May 2023 to May 2025 were selected as the SAdVP group,175 children with mild adenovirus pneumonia(MAdVP)admitted during the same period in Xi'an Union Hospital were selected as the MAdVP group,and 175 healthy children who underwent physical examinations at Xi'an Union Hospital were selected as the con-trol group.IBI and SAA/hs-CRP ratio were calculated for all subjects.According to the prognosis of children with SAdVP,they were divided into poor group and good group.Multivariate Logistic regression was used to analyze the influencing factors of poor prognosis in children with SAdVP.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive efficacy of IBI and SAA/hs-CRP ratio alone and in combina-tion for the poor prognosis of children with SAdVP.Results The IBI and SAA/hs-CRP ratio of the SAdVP group were higher than those of the MAdVP group and the control group,and the IBI and SAA/hs-CRP ratio of the MAdVP group were higher than those of the control group,and the differences were statistically signifi-cant(P<0.05).There were 123 cases in the good group and 52 cases in the poor group.The proportion of ARDS patients,the proportion of patients with circulatory system complications,IBI,SAA/hs-CRP ratio,pro-calcitonin levels in the poor group were higher than those in the good group,and the differences were statisti-cally significant(P<0.05).The results of multivariate Logistic regression analysis showed that ARDS,circu-latory system complications,increased IBI,and increased SAA/hs-CRP ratio were independent risk factors for poor prognosis in children with SAdVP(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of IBI,SAA/hs-CRP ratio alone and their combination for predicting the poor prognosis of children with SAdVP was 0.812,0.801 and 0.893 respectively.The AUC of the combination of the two to predict the poor prognosis of children with SAdVP was greater than that of IBI or SAA/hs-CRP ratio alone(Z=3.277,3.196,P<0.05).Conclusion IBI and SAA/hs-CRP ratio are increased in children with SAdVP,and they are both independent risk factors for poor prognosis of children with SAdVP.The combination of IBI and SAA/hs-CRP ratio has a high predictive efficiency for the poor prognosis of children with SAdVP.