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黄芪保心汤治疗介入术后气虚血瘀型不稳定型心绞痛OA

Research on the application effect of Huangqi Baoxin Decoction in unstable angina pectoris patients with the syndrome of blood stasis due to qi deficiency after percutaneous coronary intervention

中文摘要英文摘要

目的 探讨黄芪保心汤在气虚血瘀型不稳定型心绞痛患者介入手术治疗后的应用效果.方法 选择2023年1月—2025年1月在洛阳市中医院接受经皮冠状动脉介入治疗(PCI)治疗的178例不稳定型心绞痛患者为研究对象,所有患者均为气虚血瘀证型.通过随机数字表法将所有患者分为2组,每组89例.对照组术后接受常规西药治疗,观察组在对照组的基础上联合服用黄芪保心汤.所有患者均接受4周的治疗,比较2组治疗前和治疗后的血脂水平、炎性因子水平、血管内皮功能、动态心电图和中医证候积分.记录用药期间不良反应发生情况.结果 观察组治疗后的血脂中TC、TG、LDL-C水平、炎性因子水平、中医证候积分均低于对照组,HDL-C高于对照组,血管内皮功能和动态心电图治疗比对照组显著改善,差异均有统计学意义(P<0.05).2组不良反应发生情况比较,差异无统计学意义(P>0.05).结论 黄芪保心汤可显著改善气虚血瘀型不稳定型心绞痛患者PCI术后的血脂、炎症指标、血管内皮功能及临床症状,且安全性良好.

Objective To investigate the application effect of Huangqi Baoxin Decoction in unstable angina pectoris patients with the syndrome of blood stasis due to qi deficiency after percutaneous coronary intervention(PCI).Methods A total of 178 patients with unstable angina pectoris who underwent PCI in the Luoyang Hospital of Traditional Chinese Medicine from January 2023 to January 2025 were selected as the study subjects.All the patients were identified as having the syndrome of blood stasis due to qi deficiency.By means of a random number table,they were randomly allocated into two groups,each consisting of 89 individuals.After the surgical procedure,the control group was given standard Western medicine treatment,whereas the observation group received Huangqi Baoxin Decoction on top of the conventional treatment.Both groups received a four-week treatment course.The blood lipid levels,inflammatory cytokine levels,vascular endothelial function,dynamic electrocardiogram(ECG)findings,and traditional Chinese medicine(TCM)syndrome scores were compared between the two groups before treatment and four weeks after medication.Adverse reactions during the medication period were recorded.Results Four weeks after medication,the observation group showed significantly lower blood lipid levels,inflammatory cytokine levels,and TCM syndrome scores compared to the control group,and the vascular endothelial function and dynamic ECG findings were significantly improved in the observation group compared to the control group(P<0.05).There was no statistically significant difference in the occurrence of adverse reactions between the two groups(P>0.05).Conclusion Huangqi Baoxin Decoction can significantly improve the blood lipid levels,inflammatory markers,vascular endothelial function,and clinical symptoms in unstable angina pectoris patients with the syndrome of blood stasis due to qi deficiency after PCI,with good safety.

张保珠;赵鹏;王瑞婷;郭敏

洛阳市中医院心血管内科,河南 洛阳 471000洛阳市中医院心血管内科,河南 洛阳 471000陕西中医药大学第二附属医院心内科,陕西 咸阳 710061洛阳市中医院心血管内科,河南 洛阳 471000

医药卫生

不稳定型心绞痛经皮冠状动脉介入治疗气虚血瘀黄芪保心汤

unstable angina pectorispercutaneous coronary interventionblood stasis due to qi deficiencyHuangqi Baoxin Decoction

《吉林中医药》 2026 (6)

723-727,5

河南省中医药科学研究专项课题(2023ZY2174)河南省中医药学科拔尖人才项目(豫卫中医药科教函[2025]14号)

10.13463/j.cnki.jlzyy.2026.06.010

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