基于"因瘀致毒,瘀毒致变"探讨心力衰竭合并利尿剂抵抗的辨治OA

Heart failure combined with diuretic resistance falls within the category of"diseases caused by blood stasis and toxins",and its core pathogenesis evolution features"toxins caused by blood stasis and lesions caused by blood stasis and toxins".Traditional Chinese medicine can play a role in improving heart failure complicated with diuretic resistance through anti-inflammation,antioxidant and vascular endothelial function regulation and other pathways.Based on the theory of blood stasis and toxins,combined with modern medical research,this paper systematically explores the interaction between blood stasis and toxins and factors such as water dampness,qi stagnation,and yang deficiency,as well as the dynamic pathogenesis in the progression of this disease.It states that blood stasis blocks the heart meridian,which over time transforms into heat and generates toxins.The toxins and blood stasis accumulate and block sanjiao,hindering the distribution of qi,blood and body fluids,which leads to a poor transformation of body fluids and persistent edema,thereby aggravating heart failure and causing a resistance to diuretics.While detoxification and promoting blood circulation count as the fundamental treatment methods for this disease,treatment methods are proposed in this paper that take into account benefiting qi and warming yang,dispersing the liver and regulating qi,strengthening the spleen and promoting diuresis,as well as using insect drugs to unblock meridians and detoxify based on different concurrent syndromes.This study underscores the therapeutic principle of"removing blood stasis and detoxifying,strengthening and consolidating the body's resistance",aiming to improve cardiac function and diuretic sensitivity by harmonizing qi and blood,unblocking meridians,detoxifying and promoting diuresis.