液-液相分离的发生机制及其在肿瘤进展中的关键作用OA

Liquid-liquid phase separation(LLPS)can drive the spontaneous aggregation of biomacromolecules such as proteins and nucleic acids within cells,forming biomolecular condensate(BMC)with liquid-like properties,also known as membrane-less organelle(MLO).Studies have found that the formation,regulation,and dysregulation of LLPS of key proteins are closely related to processes such as tumor initiation,progression,metastasis,and angiogenesis.This article systematically reviews the mechanism of LLPS and discusses its role at different stages of tumor development,aiming to provide a theoretical basis for treating malignant tumors by targeting the LLPS of key proteins.