高效液相法测定颜料中氯己定等3种防腐剂的含量OA

Pigments are widely used in industry and daily life,particularly in applications such as painting and coatings.Due to their composition,which includes pigments,fillers,dyes,natural components,and solvents(e.g.,water),these materials provide an environment conducive to the growth of microorganisms and molds.Therefore,preservatives are inevitably used to extend their service life.Common preservatives such as chlorhexidine,chlorhexylphenol,and hexamidine diisethionate are effective but may pose potential health risks.Therefore,it is necessary to establish reliable detection methods for preservatives to monitor and control their limits.In this study,a new analytical method was developed for the determination of chlorhexidine,chloroxylenol,and hexamidine diisethionate in paints using high-performance liquid chromatography.Methanol was employed as the extraction solvent in combination with ultrasonic extraction,and quantification was performed using an external standard.A linear correlation was observed between peak area and analyte concentrations over the range of 0.50～50.0 mg/L,with the correlation coefficients exceeding 0.995 for all compounds.The limits of determination(LOD)were 0.05 mg/L for chlorhexidine,0.05 mg/L for hexamidine diisethionate,and 0.1 mg/L for chlorhexylphenol.The average spiked recoveries were 95%～110%,and the repeatability for all analytes was below 1%(RSD,n=7).This method is simple,rapid,accurate,reliable,and suitable for the determination of chlorhexidine,chlorodicresol,and hexamidine diisethionate in pigments-based materials.