病理性心肌肥厚动物模型的研究进展OA

Pathological cardiac hypertrophy(PCH)is a crucial pathological process in the development of heart failure from a variety of cardiovascular disorders.To elucidate its pathogenesis and explore effective therapeutic strategies,worldwide researchers have established multiple animal models of PCH across different species,including mice,rats,rabbits,cats,dogs,sheep,and pigs.Despite significant progress in existing research,systematic comparative studies of different modeling methods remain scarce in large animals with genetic structures more closely aligned with humans.This paper compares the benefits and drawbacks of various model animals while methodically reviewing the most recent developments in PCH animal models.It focuses on the principles,phenotypic traits,and applicability of various modeling approaches.Overall,animal models of PCH show distinct strengths across different pathogenic mechanisms and research settings.However,in large-animal models,systematic comparative studies and unified evaluation criteria are still lacking,which limits their practical application to some extent.Future work should place greater emphasis on phenotype-oriented model design and on developing large-animal models that can stably reproduce specific disease stages to promote their clinical translation.