镧系近红外二区发光材料在生物传感与诊疗中的应用进展OA

With the improvement of people's living standards,the demand for refined health management is increasingly growing,putting forward higher requirements for early diagnosis and precise treatment of diseases.Lanthanide-based near-infrared Ⅱ region(NIR-Ⅱ)luminescent materials,with advantages of narrow-band emission,high tissue penetration,low photon scattering,and minimal autofluorescence interference,have overcome the limitations of traditional optical materials,and have demonstrated significant value in the fields of biological detection and disease theranostics,emerging as key candidate materials for precision medicine.In this review,the application progress of lanthanide NIR-Ⅱ luminescent materials in biological detection and disease management were systematically summarized,covering their roles in biosensing,bioimaging(Including structural imaging,functional imaging,and multimodal imaging),as well as tumor therapy(Imaging-guided surgery and theranostics).Additionally,the limitations and challenges associated with their biomedical applications were discussed.By elaborating on these aspects,this paper aimed to provide valuable insights and references for the material design optimization and clinical translation of lanthanide NIR-Ⅱ luminescent materials,thereby advancing the fields of biological detection and disease treatment.