血府逐瘀浸膏质量智能评价体系构建:基于物理指纹图谱、机器视觉与大语言模型的联合应用OA
Construction of Intelligent Quality Evaluation System for Xuefu Zhuyu Extract:Combined Application of Physical Fingerprint,Machine Vision and Large Language Model
为解决中药浸膏生产中依赖单一指标或经验判断浓缩终点的局限,该研究以血府逐瘀浸膏为对象,创新性提出"物理指纹图谱+机器视觉+大语言模型"的多模态融合策略智能质控体系.通过筛选密度、pH值等7项核心物理指标,并进行标准化处理构建物理指纹图谱;然后结合马氏距离剔除异常样本,使用"CRITIC+熵权+TOPSIS法"计算综合得分,并以0.6为合格阈值,将100批样本分为62批合格与38批不合格样本;同时采集并提取浸膏图像特征构建了6种机器学习模型,对比结果显示,XGBoost模型的性能最优,准确率、精确率、召回率、F1分数、AUC分别达0.933 3、1.000 0、0.833 3、0.909 1、0.963 0.在此基础上进一步开发集成了大语言模型的智能评估平台,可在10 s左右完成分析并生成可操作的工艺建议.该体系为血府逐瘀浸膏提供了"客观分级+快速预测+智能建议"一体化质控方案,也为中药浸膏类中间体的多维度质量评价提供了可复用的技术范式,将有力推动中药生产向"数据驱动"转型.
In order to solve the limitation of relying on a single index or experience to judge the con-centration end point in the production of traditional Chinese medicine extract,this study took Xuefu Zhuyu extract as the object,and innovatively proposes an intelligent quality control system of"physi-cal fingerprint+machine vision+large language model"multi-modal fusion strategy.Seven core physical indexes such as density and pH value were screened and standardized to construct physical fingerprint.Then,the abnormal samples were eliminated by Mahalanobis distance,and the compre-hensive score was calculated by"CRITIC+entropy weight+TOPSIS"method.With 0.6 as the quali-fied threshold,100 batches of samples were divided into 62 batches of qualified samples and 38 batches of unqualified samples.At the same time,the extract image features were collected and ex-tracted,and six machine learning models were constructed.Among them,the XGBoost model had the best performance,with accuracy,precision,recall,F1 score,and AUC reaching 0.933 3,1.000 0,0.833 3,0.909 1,and 0.963 0,respectively.Based on this,an intelligent assessment platform integrating large language models can be further developed,which can complete the analy-sis and generate actionable process suggestions within about ten seconds.This system provides an in-tegrated quality control scheme of"objective grading+rapid prediction+intelligent"suggestion for Xuefu Zhuyu extract,and also provides a reusable technical paradigm for multi-dimensional quality evaluation of Chinese medicine extract intermediates,which effectively promotes the transformation of Chinese medicine production to"data-driven".
沙鑫;常淏;宋纹;余河水;李正;李文龙
天津中医药大学 中药制药工程学院,天津 301617||现代中医药海河实验室,天津 301617天津中医药大学 中药制药工程学院,天津 301617||现代中医药海河实验室,天津 301617天津宏仁堂药业有限公司,天津 300380天津中医药大学 中药制药工程学院,天津 301617||现代中医药海河实验室,天津 301617||天津市中药智能制药与绿色制药重点实验室,天津 301617天津中医药大学 中药制药工程学院,天津 301617||现代中医药海河实验室,天津 301617||天津市中药智能制药与绿色制药重点实验室,天津 301617天津中医药大学 中药制药工程学院,天津 301617||现代中医药海河实验室,天津 301617||天津市中药智能制药与绿色制药重点实验室,天津 301617
化学化工
血府逐瘀浸膏物理指纹图谱机器视觉大语言模型质量控制
Xuefu Zhuyu extractphysical fingerprintmachine visionlarge language modelquality control
《分析测试学报》 2026 (6)
1212-1220,9
国家重点研发计划(2023YFC3504502)现代中医药海河实验室-天津宏仁堂药业有限公司合作项目(XMH2022004)
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