中药大品种二次开发关键技术研究进展及相关思考:以血府逐瘀制剂为例OA

Traditional Chinese medicine preparations still have potential safety hazards due to com-plex components,vague pharmacodynamic material basis,insufficient quality controllability and un-clear mechanism of action,which affect their popularization and internationalization.In response to the above problems,the field of traditional Chinese medicine has gradually formed a systematic re-development idea with the core concept of"new use of old drugs and renewal of classics",and pro-moted the in-depth excavation and re-evaluation of large varieties of traditional Chinese medicine.With the in-depth application of artificial intelligence,process analysis technology,network pharma-cology,mass spectrometry technology and quality by design concept in the research of traditional Chi-nese medicine,the modernization and scientific development of large varieties of traditional Chinese medicine ushered in new opportunities.In this paper,Xuefu Zhuyu preparation,a typical large vari-ety of traditional Chinese medicine for promoting blood circulation and removing blood stasis,was taken as the research object.For the first time,the key technical system involved in its secondary de-velopment was systematically sorted out,including five dimensions:quality control,mechanism analysis,clear efficacy,efficacy improvement and international recognition.At the same time,combined with the application examples of artificial intelligence and large language model,the rele-vant technical paths were optimized and the common experience was refined to explore the future de-velopment direction of large varieties of traditional Chinese medicine,so as to provide a reference paradigm for the modernization and upgrading of similar varieties.