国医大师潘敏求基于"脾-肾气化协同轴"诊治抗肿瘤药物所致骨髓抑制经验总结OA

This article introduces the clinical experience of National Chinese Medicine Master Professor Pan Minqiu(hereinafter respectfully referred to as"Master Pan")in the diagnosis and treatment of myelosuppression induced by antitumor drugs based on the"spleen-kidney Qi transformation synergistic axis".Master Pan believes that the onset of myelosuppression induced by antitumor drugs is closely associated with dysfunction of the spleen and kidney,with the root cause of the destruction of the"spleen-kidney Qi transformation synergistic axis"by drug toxicity.Damage to the spleen leads to insufficient generation of Qi and blood,while damage to the kidney impairs its normal function of storing essence and transforming marrow,resulting in the retention of pathogenic toxins in bone marrow,which further obstructs the generation and circulation of Qi and blood.In clinical practice,Master Pan emphasizes syndrome differentiation and stag-ing and proposes the method of strengthening the spleen and tonifying the kidney to treat this disease.He mainly uses the modified prescriptions of Sijunzi decoction combined with Danggui Buxue decoction and Fufang Busui decoction,thereby supplementing Qi and strengthening the spleen to support the source of the generation of Qi and blood and nourishing kid-ney-essence to consolidate the root.He skillfully uses Astragalus membranaceus and Codonopsis pilosula to strengthen the spleen and benefit Qi and applies prepared Radix Rehmanniae and Lycium barbarum L.to tonify the kidney and nourish essence.Furthermore,he emphasizes the importance of dynamic regulation,adjusting doses based on chemotherapy stages and changes in hemogram parameters and achieving the balance between improving the hematopoietic function of bone marrow and reducing the toxicity and side effects of chemotherapy,thereby realizing the unity of"treatment aiming at its root causes"and"symptomatic treatment".A typical case is attached as evidence.