基于熵病理论探讨胃癌"虚-郁-毒-衰"病机演变及治疗思路OA
Exploration of the pathogenesis evolution and treatment strategies of gastric cancer from the perspective of deficiency-stagnation-toxicity-exhaustion based on the theory of entropy disease
基于熵病理论系统探讨胃癌中医病机演变规律,提出以"虚-郁-毒-衰"为核心的分期传变模型."虚"为中焦虚损,负熵摄入不足,熵增起始;"郁"为浊邪郁结,熵值剧增;"毒"为癌毒内生,熵增失控;"衰"为元气衰败,熵增极限.确立以"调熵复序"为总则的分期辨治策略,分别予健脾益气,扶正摄熵,理气解郁,化浊降熵,解毒散结,抑癌调熵,固本培元,回阳控熵等治法.通过整合熵病理论与中医病机模型,为从系统有序度角度理解胃癌本质、指导中西医结合防治胃癌提供新的理论框架与研究思路.
Based on the entropy disease theory,this paper systematically explores the evolutionary patterns of TCM pathogenesis in gastric cancer and proposes a staged progression model centered on"deficiency-stagnation-toxicity-exhaustion."Among them,"deficiency"refers to the impairment of the middle energizer and insufficient intake of negative entropy,marking the onset of entropy increase;"stagnation"involves the accumulation of turbid pathogens,leading to a sharp rise in entropy value;"toxicity"signifies the internal generation of cancer toxins,resulting in an uncontrolled increase in entropy;and"exhaustion"represents the collapse of primordial qi,reaching the limit of entropy increase.On this basis,a staged treatment based on syndrome differentiation based on the principle of"regulating entropy and restoring order"is established,which includes methods such as strengthening the spleen and boosting qi to support healthy qi and absorb entropy,regulating qi and relieving stagnation to resolve turbidity and reduce entropy,detoxifying and dissipating nodules to suppress tumor progression and regulate entropy,and consolidating the root,fostering the source,and restoring yang to control entropy.By integrating the entropy disease theory with the TCM pathogenesis model,this paper provides a new theoretical framework and research direction for understanding the nature of gastric cancer and guiding the prevention and treatment of gastric cancer through integrated Chinese and Western medicine from the perspective of systemic order.
刘泽豪;徐淼;朱世杰;谢虹亭;谢飞宇;周磊;薛鹏
中国中医科学院望京医院肿瘤科,北京 100102北京中医药大学研究生院,北京 100029中国中医科学院望京医院肿瘤科,北京 100102中国中医科学院望京医院肿瘤科,北京 100102浙江省肿瘤医院肿瘤科,杭州 310022中国中医科学院望京医院肿瘤科,北京 100102中国中医科学院望京医院肿瘤科,北京 100102
医药卫生
熵病胃癌病机演变
entropy diseasegastric cancerpathogenesis evolution
《长春中医药大学学报》 2026 (6)
639-644,6
国家自然科学基金项目(82575164,82505692)
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