术前载脂蛋白B/载脂蛋白A1比值与非体外循环冠脉搭桥术后急性肾损伤风险的关联研究OA

Objective:To investigate the association between preoperative apolipoprotein B/apolipoproteinA1 ratio(ApoB/ApoA1)and the risk of developing acute kidney injury(AKI)following off pump coronary artery bypass grafting(OPCABG).Methods:A retrospective cohort study was conducted.Clinical data from 107 patients who underwent OPCABG were collected.Patients were divided into an AKI group(n=34)and a non-AKI group(n=73)based on postoperative occurrence of AKI defined by KDIGO criteria.Data,including gender,age,comorbidities,preoperative laboratory parameters(ApoB/ApoA1 ratio,albumin,hemoglobin,serum creatinine),and surgical approach,were collected and compared between the two groups.Univariate and multivariate Logistic regression analyses were performed to identify independent risk factors for postoperative AKI.Results:The preoperative ApoB/ApoA1 ratio was higher in the AKI group than in the non-AKI group(P<0.05).Univariate analysis revealed that body weight and ApoB/ApoA1 ratio were influencing factors for AKI(P<0.10).Multivariate Logistic regression analysis demonstrated that after adjusting for age,body weight,and preoperative serum creatinine,a higher preoperative ApoB/ApoA1 ratio remained an independent risk factor for AKI following OPCABG(P<0.05).Conclusion:An elevated preoperative ApoB/ApoA1 ratio is independently associated with an increased risk of AKI after OPCABG.This ratio may serve as a potential biomarker for preoperative assessment of renal injury risk.