白藜芦醇治疗糖尿病的药理作用机制研究进展OA

Diabetes mellitus(DM)is a set of metabolic diseases characterized by disordered glucose metabolism.Its global incidence remains persistently high,and long-term complications can affect multiple organs,including the heart,kidney,eye,and nervous system,posing a severe threat to human health.Resveratrol(RSV)is a natural phytoalexin widely distributed in plants such as grapes,peanuts,and Reynoutria japonica Houtt.It mainly exists in the trans configuration,which exhibits greater stability and bioactivity.RSV possesses multiple pharmacological properties,including antioxidant,anti-inflammatory,and metabolic regu-latory effects,and has emerged as a research hotspot in the prevention and treatment of diabetes in recent years.Based on recent domestic and international studies,this paper systematically reviews the pharmacological mechanisms of RSV in the treatment of diabetes,including improving insulin resistance,regulating glucose and lipid metabolism,inhibiting oxidative stress and inflam-matory responses,protecting pancreatic β-cells,and delaying diabetic complications.It also analyzes the limitations of current re-search and future directions,aiming to provide a theoretical basis for the clinical application of RSV in diabetes therapy and the development of related drugs.