溃疡性结肠炎湿热病机与湿热伏邪理论的现代研究OA

The refractory character of ulcerative colitis(UC)is related to the basic pathophysiology of"lingering dampness-heat transforming into a latent pathogen",which captures the essence of the dampness-heat latent pathogen hypothesis.This academic discussion methodically delineates current research progress using this methodology.During the initial stage,dampness-heat alters the gut microbiota-metabolite axis,promoting pathogen latency and pro-inflammatory metabolite accumulation—the material foundation of the latent pathogen.In the progressive stage,dampness-heat congeals to initiate immune-inflammatory cascades,indicating a shift from quiescence to activation as an effector state.In the chronic persistent stage,the entrenched pathogen causes epigenetic changes that maintain inflammatory gene expression,resulting in a self-perpetuating"inflammation-epigenetics"cycle-the mechanism of pathological consolidation.Chinese medicine based on this idea offer multi-target therapeutic benefits at all stages.The purpose of this academic discussion is to provide a modern scientific foundation for the dampness-heat latent pathogen theory,as well as a theoretical underpinning for its clinical application.